自体外周血造血干细胞支持下高剂量化疗对晚期乳腺癌患者的生活质量研究
DOI: 10.3971/j.issn.1000-8578.2015.02.010
邸立军（：并列第一作者）,
严颖,
任军,
余靖,
吕敏,
周心娜,
姜晗昉,
宋国红,
尤渺宁,
张洁,
朱步东,
林晓琳,
梁旭,
王小利,
王超颖,
祝毓琳,
贾军,
车利,
邵彬,
黄晓蕾
Keywords: 乳腺癌,生活质量,自体外周血造血干细胞支持下高剂量化疗,Multi-factors Affect Cardiac Toxicity in Radiotherapy on Left-sided Breast Cancer,Effect of Neoadjuvant Chemotherapy Cycles on Pathologic Complete Response Rate Under Different Estrogen Receptor Status of Breast Cancer,Review of Targeted Therapy for Breast Cancer with BRCA Genes Mutation,Autophagic Cell Death Induced by GANT61 Inhibits Proliferation of Human Breast Cancer Cell Line MCF-7,Effect of Thyroid Hormone Receptor βΔ on Proliferation and Apoptosis of Rat Breast Cancer Cells SHZ-88,Progress on FOXP3 Expression in Breast Cancer Cells,Effect of Hormones from Adrenal Gland on Breast Cancer Metastasis in Mice,Effect of SAHA on Proliferation and Apoptosis of Breast Cancer Cells MDA-MB-435 and Related Mechanism,Analysis E-cad and VEGF Expression in Triple-negative Breast Cancer of Han and Uygur,Regulations and Roles of Breast Cancer Stem Cells,Prediction of Disease Specific Survival Rates by Genes Associated with Relapse of Breast Cancer,Correlation Between Tumor Associated Macrophages and CXCL12 Expression in Different Breast Tissues,Effects of NRP-1 Overexpression on Biological Behaviors of Breast Cancer Cell Lines MDA-MB-231 and SK-BR-3,Effect of Operation Incision Selection on Success rate of Sentinel Lymph Node Biopsy and Subcutaneous Hydrops in Breast Cancer,Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues
Abstract:
摘要 目的 分析自体外周血造血干细胞支持下高剂量化疗对于晚期乳腺癌化疗前后生活质量影响，为选择有效改善患者生活质量的干预措施提供依据。 方法 回顾性分析25例病例组行自体外周血造血干细胞支持下高剂量化疗的晚期乳腺癌患者临床资料，同期选取接受常规方案化疗的22例晚期乳腺癌患者为对照组。采用简明 健 康 状 况 调 查 量 表SF-36（MOS36-item short forum healthsurvey）的缩减版本SF-12量表作为问卷调查表。在第1个时间点（T1）为治疗前，第2个时间点（T2）为第2周期高剂量化疗前和第4周期常规治疗前，第3个时间点（T3）为高剂量化疗结束3月随访时和常规剂量化疗结束后3月进行调查随访。采用t检验进行统计分析。结果 高剂量化疗组和常规剂量组患者生活质量8个维度评分T2较T1均显著下降（P<0.05），T3较T1两组患者活力和社会功能维度仍显著下降（P<0.05），其他维度差异无统计学意义。T2时间点高剂量化疗组较常规剂量化疗组总体健康、生理功能、活力和社会功能维度显著下降（P<0.05），T1和T3时间点高剂量化疗组和常规剂量组差异无统计学意义。结论 自体外周血造血干细胞支持下高剂量化疗导致乳腺癌患者总体健康、生理功能、活力和社会功能显著下降，但患者高剂量化疗缩短了治疗时间，使患者可更快的恢复正常生活
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