同期调强放疗联合内分泌治疗对局部晚期前列腺癌乏力症状的影响
DOI: 10.3971/j.issn.1000-8578.2016.06.014
Keywords: A Metaanalysis,Prognosis of Clinical Stage ⅢA(N2) Non-small Cell Lung Cancer Patients Received Radiotherapy,Nitric Oxide-donor Drugs and Prostate Cancer: An Update,Application of Helical Tomotherapy in Treatment for Head and Neck Cancer,MR Apparent Diffusion Coefficient Predicts Sensitivity of Nasopharyngeal Carcinoma to Radiotherapy and Related Factors,Advances of Dose-painting Radiotherapy,Comparison of Clinical Value of Transrectal Ultrasound, Contrast-enhanced Ultrasonography and Dynamic Contrast Material-enhanced Magnetic Resonance Imaging for Detecting Prostate Carcinoma,Application Progress of Helical Tomotherapy in Central Nervous System Neoplasms,Effect of Tumor Length, Maximum Diameters and Volume on Prognosis of Stage N0 Esophageal Squamous Cell Carcinoma Patients,Comparison of 6th and 7th Editions of AJCC/UICC TNM Staging for Esophageal Cancer#br# Patients Received Radiotherapy,Clinical Observation on Cyberknife Radiosurgery Treatment for Unresectable Primary Intrahepatic Cholangiocarcinoma,Progress of Biological and Therapeutic Effect of Manganese Superoxide Dismutase in Tumor Radiotherapy,Effect of CRM1 Inhibitor KPT-185 on Growth of Human Prostate Cancer Cells
Abstract:
摘要 目的 评价调强放疗联合内分泌治疗对局部晚期前列腺癌乏力症状的影响。方法 对符合纳入标准的局部晚期前列腺癌患者采用同期三维适形调强放疗联合内分泌治疗。采用FSI（Fatigue Symptom Inventory）量表进行长期问卷随访，调查时间分别为治疗前（A）、治疗结束后（B）、治疗结束3月（C）、12月（D）、24月（E）、36月（F）、48月（G）。随访内容包括疲劳程度、对生活质量影响程度及上周疲劳持续时间3个维度。Logistic多分类回归模型评价危险因素。结果 共97例局部晚期前列腺癌患者纳入研究。中位随访时间43.9月。乏力指数与PSA水平、Gleason评分、ECOG评分及文化程度相关（P<0.05）；年龄和临床分期与乏力指数无关（P>0.05）；多分类回归分析显示PSA水平和ECOG评分是癌症相关性乏力的独立危险因素。疲劳程度在各个随访时间点未体现出差异（P>0.05），但最严重疲乏程度发生在时间点B和C；时间点C、D、E、F和G的疲乏对生活影响积分均高于基线评价，且差异有统计学意义（P<0.05），尤其是对日常活动影响积分、注意力积分和情绪积分。疲乏持续时间呈现波动状态，时间点D、E、F呈明显上升，差异有统计学意义（P<0.05）。结论 ECOG评分高、Gleason≥8分、PSA＞20ng/ml、且文化程度高的局部晚期前列腺癌患者，在接受同期放疗联合内分泌治疗后，要关注乏力对生活质量产生的影响，特别是在对日常活动、注意力和情绪方面
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