内质网应激/未折叠蛋白反应促进肿瘤侵袭的研究进展
DOI: 10.3971/j.issn.1000-8578.2017.04.013
Keywords: 内质网应激,侵袭,血管内皮生长因子,上皮间质转化,葡萄糖调节蛋78,前梯度蛋白2,细胞外基质,miR-601 Suppresses Migration and Invasion of Non-small Cell lung Cancer Cells by Targeting MMP-17,Effects of Sanguinarine on Invasion, Migration and Wnt/β-catenin Signaling Pathway of Lung Adenocarcinoma Cells,Expression and Functional of LncRNA XIST in MCF-7 Breast Cancer Cells,Effect of Down-regulation of HOXB7 Expression on Proliferation, Migration and Invasion Abilities of Hepatoma Cells,Curcumin Reverses Ionizing Radiation-induced Epithelial Mesenchymal Transformation of Non-small Cell Lung Cancer A549 Cells,Effects of miR-144 on Proliferation, Migration, Invasion and PI3K Pathway of Pancreatic Cancer SW1990 Cells,G6PD对大肠癌细胞生长侵袭的影响及其与HKⅡ的相关性,Effects of MicroRNA-4465 on Apoptosis and Invasion of Colon Cancer Cells,Effect of FBXL20 on Proliferation, Migration and Invasion of Gastric Cancer Cells,Expression of HIF-1α and VEGF in Glioma A172 Cells After Gene Intervention,Influence of NRP-1 Monoclonal Antibody on Growth of Breast Cancer Xenografts in Nude Mouse,Tumor-associated Macrophages Promote Invasion and Metastasis of Cervical Cancer,Ampelopsis Regulates Invasive Activity and Invasion Gene Expression of Hepatocellular Carcinoma HepG2 Cell Line Through Dermcidin Protein,Expression of Circular RNA ciRS-7 and Its Effect on Invasion and Migration of Triplenegative reast Cancer Cells,Role of Gadd45 Protein Family in Tumorigenesis and Development
Abstract:
摘要 内质网应激/未折叠蛋白反应促进肿瘤侵袭是肿瘤调控的新机制，适度的内质网应激不仅可以保护细胞还能促进肿瘤细胞侵袭。许多研究表明内质网应激/未折叠蛋白反应与肿瘤的发生发展密切相关，且能通过上调血管内皮生长因子、葡萄糖调节蛋白78、 前梯度蛋白2的表达、促进上皮间质转化、降解细胞外基质等方式促进肿瘤侵袭，了解内质网应激/未折叠蛋白反应与肿瘤侵袭性之间的关系可能为肿瘤治疗提供新方向。本文将对内质网应激/未折叠蛋白反应促进肿瘤侵袭的相关机制作一综述
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