双侧原发乳腺癌预后的相关因素分析
DOI: 10.3971/j.issn.1000-8578.2015.02.011
Keywords: Partial Versus Radical Nephrectomy,Relationship of Macrophage Migration Inhibitory Factor Expression with Clinicopathologic Features and Prognosis of Cardiac Carcinoma Patients,Advance of Prognostic Markers of Cervical Cancer,Correlation of CD68+ Tumor-associated Macrophages Number with Ki-67 Expression and Prognosis of Patients with Primary Hepatocellular Carcinoma,Prognostic Value of Circulating Tumor Cells for Metastatic Prostate Cancer: A Metaanalysis,Metaplastic Carcinoma of Breast with Mesenchymal Differentiation: 28 Cases Report,Predictive Value of C-reactive Protein/Albumin Ratio on Prognosis of Patients with Primary Hepatocellular Carcinoma,Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer,Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues,Prognosis Factors for Patients with Stage pT3N0M0 Thoracic Esophageal Squamous Cell Carcinoma after Radical Resection,Value of 21-gene Assay in Treatment Decisions for Hormone Receptor-positive Nodepositive Early Breast Cancer
Abstract:
摘要 目的 探讨双侧原发性乳腺癌（bilateral primary breast cancer，BPBC）的临床病理特征和预后的影响因素。方法 回顾北京大学人民医院乳腺中心收治的68名双侧原发性乳腺癌患者的临床病理资料，分析双侧乳腺癌临床和病理特征和相关性，并对预后影响因素进行单因素和多因素分析。结果 双侧原发性乳腺癌发病率占同期全部乳腺癌患者的3.2%。BPBC患者发病年龄小于单侧乳腺癌患者（P=0.007）。单因素分析结果提示，以12月或24月作为双侧肿瘤发病时间间隔来定义同时性双侧原发性乳腺癌（synchronous bilateral primary breast cancer，sBPBC）与异时性双侧原发乳腺癌（metachronous bilateral primary breast cancer，mBPBC）时，sBPBC患者预后劣于mBPBC患者（P=0.018，P=0.000）；第二原发肿瘤病理类型为浸润性小叶癌患者预后劣于浸润性导管癌（P=0.036）。多因素分析结果提示肿瘤分期、双侧乳癌发病间隔时间和第二原发肿瘤激素受体表达情况是影响BPBC患者预后的主要因素（P=0.02，P=0.02，P=0.049）。结论 BPBC发病年龄较早；sBPBC患者比mBPBC预后更差；肿瘤分期、双侧乳癌发病间隔时间和第二原发肿瘤的病理类型以及激素受体表达情况是影响BPBC患者预后的主要因素
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