缺氧相关的miRNA-210在肿瘤中的研究进展
DOI: 10.3971/j.issn.1000-8578.2018.17.1457
Keywords: A Scientometric Analysis,A Case Report of Four Primary Malignant Tumors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer,Advances of 125I Radioactive Particle Chain Intracavitary Brachytherapy,Expression of Infiltrating NK Cell Surface Receptors in Peripheral Blood and Cancer Tissues of Patients with Esophageal Squamous Cell Carcinoma,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Progress of Stimulation Response Strategy Based on Nanomaterials in Tumor Therapy,Advances in Molecular Mechanisms of Early Bone Metastasis,Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm,Advances of Ribonucleotide Reductase Inhibitors on Cancer
Abstract:
摘要 肿瘤组织失控性增殖及其内部新生血管网的相对不足导致氧气供应不足，低氧是肿瘤微环境的重要特征，低氧环境可激活肿瘤细胞中低氧诱导因子（hypoxia-inducible factors, HIFs）的表达并诱导一系列miRNAs（microRNAs, miRs）含量发生变化。miRNA是一种小的、非编码RNA，可和mRNA3’端非编码区结合，在转录后水平调节基因的表达，miR-210作为最主要的HIFs诱导表达的miRNA，参与肿瘤细胞多种生命活动，如肿瘤细胞线粒体代谢、血管形成、细胞周期调节、DNA断裂修复等；miR-210在大部分肿瘤患者的血清及肿瘤组织中高表达，且miR-210的表达水平与不良预后呈正相关，故miR-210可用于肿瘤的筛查、诊断和预测患者预后；随着对miR-210下游靶基因的深入研究，针对miR-210细胞信号转导通路的靶向治疗可为恶性肿瘤的治疗提供更广阔的前景
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