Treatment of Primary Central Nervous System Lymphoma: From Chemotherapy to Small Molecules

PCNSL is a highly aggressive non-Hodgkin lymphoma confined to the central nervous system (CNS), including the brain, spine, CSF, and eyes. Unlike other primary brain tumors, it often has a favorable response to both chemotherapy and radiation therapy; however, compared with lymphomas outside the CNS, survival is usually inferior. Moreover, the prognosis for PCNSL that fails to respond to first-line therapy remains poor. Even though new chemotherapy-based therapeutic approaches have improved survival, the management of this disease still poses a challenge in neuro-oncology. EPIDEMIOLOGY Section: ChooseTop of pageAbstractEPIDEMIOLOGY <