全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

Sickle Cell Anaemia- A Synopsis of the Inherited Ailment | Insight Medical Publishing

DOI: 10.21767/1989-5216.1000266

Full-Text   Cite this paper   Add to My Lib

Abstract:

Sickle Cell Anaemia (SCA) is one of the most prevalent monogenic disorders. The formation of polymerised haemoglobin leading to erythrocyte rigidity and appearance of characteristic sickle-shaped Red blood Cells (RBCs) resulting in vascular occlusion and haemolysis is central to the molecular pathogenesis of the disease. A major drawback of the disease in children is the development of cerebrovascular disease, hypoxia, and neuro-cognitive impairment. The recurrent episodes of vascular occlusion and inflammation of the vessels lead to progressive organ damage which becomes apparent with age. In addition to hydroxyurea and butyrate treatments, novel methods such as gene therapy and others to prevent complications from SCA are being evaluated. This article reviews the diagnostic approaches, therapies and advancements in SCA treatment with particular emphasis on the future perspective of research towards a cure for SCA.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133