Use of combined hormonal contraceptives for the treatment of？endometriosis-related pain: a systematic review of the evidence - Fertility and Sterility

To review the available clinical evidence on the use of combined hormonal contraceptive (CHC) agents (estrogen [E]-progestin combinations) for the treatment of endometriosis-related pain. A systematic review of the MEDLINE, Embase, and Derwent Drug File databases for prospective clinical studies. Not applicable. Women with endometriosis diagnosed by validated means. Combined hormonal contraceptive agents, active comparators, placebo, or no treatment. Endometriosis-related pain (dysmenorrhea, pelvic pain, and dyspareunia). Nine randomized controlled trials and nine observational studies met the inclusion criteria. The quality of data was low: only two of the nine randomized trials were placebo controlled, and most trials were not blinded. The CHC agents were reported to significantly reduce dysmenorrhea, pelvic pain, and dyspareunia from baseline in most studies; continuous administration seemed to be more useful than cyclic administration. The effectiveness of CHC agents for pain reduction was similar to or less than that of oral progestins and GnRH agonists. The available literature suggests that CHC treatment is effective for relief of endometriosis-related dysmenorrhea, pelvic pain, and dyspareunia; however, the supportive data are of low quality. Furthermore, insufficient data exist to reach conclusions about the overall superiority of any given CHC therapy, and the relative benefit in comparison to other approaches. Additional high-quality studies are needed to clarify the role of CHC agents and other treatments in women with endometriosis-related pain. Uso de anticonceptivos hormonales combinados para el tratamiento del dolor asociado a endometriosis: revisión sistemática de la evidencia Evaluar la evidencia clínica disponible sobre el uso de anticonceptivos hormonales combinados (combinaciones de estrógeno [E] – progestágeno) para el tratamiento del dolor asociado a endometriosis. Revisión sistemática de las bases de datos MEDLINE, Embase y Derwent Drug File para estudios clínicos prospectivos. No aplica. Mujeres con endometriosis diagnosticadas mediante métodos validados. Anticonceptivos hormonales combinados, comparadores activos, placebo, o sin tratamiento. Dolor asociado a endometriosis (dismenorrea, dolor pelviano y dispareunia). Nueve estudios controlados y randomizados y nueve estudios observacionales reunieron los criterios de inclusión. La calidad de los datos fue baja: sólo dos de los nueve estudios randomizados fueron controlados con placebo, y la mayoría de los estudios no fueron ciegos. Los anticonceptivos hormonales combinados