Synthesis and Analysis of Copper Neem？(azadirechta Indica) Soap-nitro and Ethoxy Benzothiazole Complexes For Anti-bacterial Activity Related With Skin Diseases - Synthesis and Analysis of Copper Neem？(azadirechta Indica) Soap-nitro and Ethoxy Benzothiazole Complexes For Anti-bacterial Activity Related With Skin Diseases - Open Access Pub

The solid copper(II) soap derived from Neem (Azadirechta Indica)oil and its complex with ligand containing nitrogen, sulphur and oxygen atoms like 2-amino -6-nitro benzothiazole and 2-amino- 6-ethoxy benzothiazole have been synthesized and characterised by elemental analysis, IR spectroscopy and biological studies. From the analytical data, the stoichiometry of the complex has been observed to be 1:1 (metal:ligand). The derived compounds were found active against Staphylococcus aureus,Coagulase-negative staphylococci (CoNs), Acinetobacter baumanii, Pseudomonas aeruginosa and micrococcus bacteria. These findings have high medical, industrial and economic significance as copper (II) soap and copper (II) soap complex could be harnessed in the formulation of medicated soaps. DOI10.14302/issn.2328-0182.japst-18-2522 The current global attention towards the production of biodiesel especially from non-edible sources has made research into production of non-edible vegetable oil a necessity. Biodiesel is a clean, biodegradable, non-toxic, renewable and environmentally friendly energy source made from fat and oil via transesterification processes. Neem (Azadirechta Indica) oil is generally light to dark brown, bitter and has a rather strong odour that is said to combine the odours of peanut and garlic. It comprises mainly triglycerides and large amounts of triterpenoid compounds, which are responsible for the bitter taste. It also contains azadirachtin, meliantriol, salannin, nimbin and nimbidin. 1, 2 Neem (Azadirechta Indica)oil is widely used as insecticides, lubricant, drugs for variety of diseases such as diabetes and tuberculosis. This oil could also prolong leather goods when it is applied on them. There are several methods to obtain neem (Azadirechta Indica)oil from the seeds like mechanical pressing, supercritical fluid extraction, and solvent extraction. Antiseptic soap, sometimes called anti-bacterial soap or anti-fungal soap, is a regular soap in liquid or solid form. According to Osbore and Grobe antibacterial soaps can remove 65 to 85% bacteria from human skin. Contemporary commercial antimicrobial soaps contain synthetic chemicals such as triclosan, triclorocarbanilide and chloroxylenol, most of which are thought to be car-cinogenic, mutagenic and or generate allergic reactions. 3, 4 Thiazole a heterocyclic nucleus played influential role in the advancement of different medicinally important moiety. They are mainly intrinsically toxic to microorganism especially to fungi and bacteria. Substituted benzothiazoles and phenylthiourea constitute an