Heparin monitoring is widely used to measure the anticoagulant effect of unfractionated heparin and adjust the dose to keep within the target treatment range. This technology has applications in many fields and also prospects in the future. Its application has the advantages of rapidity, high throughput and minimum sample consumption. Many point of care devices for heparin monitoring are available. The CoaguChek device only requires a small sample size, which is obtained through a fingerstick. Over the last few years, the point-of-care (POC) testing was used widely for its convenience, efficiency, and faster turnaround times.
References
[1]
Terry, S.C., Jerman, J.H. and Angell, J.B. (1979) A Gas Chromatographic Air Analyzer Fabricated on a Silicon Wafer. IEEE Transactions on Electron Devices, 26, 1880-1886. https://doi.org/10.1109/T-ED.1979.19791
[2]
Manz, A., Graber, N. and Widmer, H.M. (1990) Miniaturized Total Chemical Analysis Systems: A Novel Concept for Chemical Sensing. Sensors and Actuators B: Chemical, 1, 244-248. https://doi.org/10.1016/0925-4005(90)80209-I
[3]
Pollack, M.G., Fair, R.B. and Shenderov, A.D. (2000) Electrowetting-Based Actuation of Liquid Drop Lets for Microfluidic Applications. Applied Physics Letters, 77, 1725-1726. https://doi.org/10.1063/1.1308534
[4]
Martinez, A.W., Phillips, S.T., Butte, M.J. and Whitesides, G.M. (2007) Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays. Angewandte Chemie International Edition, 46, 1318-1320.
https://doi.org/10.1002/anie.200603817
[5]
Unger, M.A., Chou, H.P., Thorsen, T., Scherer, A. and Quake, S.R. (2000) Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography. Science, 288, 113-116. https://doi.org/10.1126/science.288.5463.113
[6]
Li, N., Hsu, C.-H. and Folch, A. (2005) Parallel Mixing of Photolithographically Defined Nanoliter Volumes Using Elastomeric Microvalve Arrays. Electrophoresis, 26, 3758-3764. https://doi.org/10.1002/elps.200500171
[7]
Baek, J.Y., Park, J.Y., Ju, J.I., Lee, T.S. and Lee, S.H. (2005) A Pneumatically Controllable Flexible and Polymeric Microfluidic Valve Fabricated via in Situ Development. Journal of Micromechanics Microengineering, 15, 1015-1020.
https://doi.org/10.1088/0960-1317/15/5/017
[8]
Sundararajan, N., Kim, D. and Berlin, A.A. (2005) Microfluidic Operations Using Deformable Polymer Membranes Fabricated by Single Layer Soft Lithography. Lab on a Chip, 5, 350-354. https://doi.org/10.1039/b500792p
[9]
Mugele, F. and Baret, J.-C. (2005) Electrowetting: From Basics to Applications. Journal of Physics: Condensed Matter, 17, R705-R774.
https://doi.org/10.1088/0953-8984/17/28/R01
[10]
Pamme, N., Eijkel, J.C.T. and Manz, A. (2006) On-Chip Free-Flow Magnetophoresis: Separation and Detection of Mixtures of Magnetic Particles in Continuous Flow. Journal of Magnetism and Magnetic Materials, 307, 237-244.
https://doi.org/10.1016/j.jmmm.2006.04.008
[11]
Akbar, M., Restaino, M. and Agah, M. (2015) Chip-Scale Gas Chromatography: From Injection through Detection. Microsystems & Nanoengineering, 1, Article No. 15039. https://doi.org/10.1038/micronano.2015.39
[12]
Lazar, I.M., Trisiripisal, P. and Sarvaiya, H.A. (2006) Microfluidic Liquid Chromatography System for Proteomic Applications and Biomarker Screening. Analytical Chemistry, 78, 5513-5524. https://doi.org/10.1021/ac060434y
[13]
Maguire, I., O’Kennedy, R., Ducrée, J. and Regan, F. (2018) A Review of Centrifugal Microfluidics in Environmental Monitoring. Analytical Methods, 10, 1497-1515.
https://doi.org/10.1039/C8AY00361K
[14]
Pol, R., Céspedes, F., Gabriel, D. and Baeza, M. (2017) Microfluidic Lab-on-a-Chip Platforms for Environmental Monitoring. TrAC Trends in Analytical Chemistry, 95, 62-68. https://doi.org/10.1016/j.trac.2017.08.001
[15]
Rivet, C., Lee, H., Hirsch, A., Hamilton, S. and Lu, H. (2011) Microfluidics for Medical Diagnostics and Biosensors. Chemical Engineering Science, 66, 1490-1507.
https://doi.org/10.1016/j.ces.2010.08.015
[16]
Na, W., Nam, D., Lee, H. and Shin, S. (2018) Rapid Molecular Diagnosis of Infectious Viruses in Microfluidics Using DNA Hydrogel Formation. Biosensors and Bioelectronics, 108, 9-13. https://doi.org/10.1016/j.bios.2018.02.040
[17]
Aref, A.R., et al. (2013) Screening Therapeutic EMT Blocking Agents in a Three-Dimensional Microenvironment. Integrative Biology, 5, 381-389.
https://doi.org/10.1039/C2IB20209C
[18]
Lee, H. and Choi, S. (2015) A Micro-Sized Bio-Solar Cell for Self-Sustaining Power Generation. Lab on a Chip, 15, 391-398. https://doi.org/10.1039/C4LC01069H
[19]
Li, L., et al. (2014) Optofluidics Based Micro-Photocatalytic Fuel Cell for Efficient Wastewater Treatment and Electricity Generation. Lab on a Chip, 14, 3368-3375.
https://doi.org/10.1039/C4LC00595C
[20]
Esquivel, J.P., et al. (2012) Fuel Cell-Powered Microfluidic Platform for Lab-on-a-Chip Applications. Lab on a Chip, 12, 74-79. https://doi.org/10.1039/C1LC20426B
[21]
Esquivel, J.P., et al. (2017) Single-Use Paper-Based Hydrogen Fuel Cells for Point-of-Care Diagnostic Applications. Journal of Power Sources, 342, 442-451.
https://doi.org/10.1016/j.jpowsour.2016.12.085
[22]
Furie, B. (2005) Thrombus Formation in Vivo. The Journal of Clinical Investigation, 115, 3355-3362. https://doi.org/10.1172/JCI26987
[23]
Soff, G.A. (2012) A New Generation of Oral Direct Anticoagulants. Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 569-574.
https://doi.org/10.1161/ATVBAHA.111.242834
[24]
Hirsh, J. and Raschke, R. (2004) Heparin and Low-Molecular-Weight Heparin. Chest, 126, 188S-203S. https://doi.org/10.1378/chest.126.3_suppl.188S
[25]
Olson, J.D., et al. (1998) College of American Pathologists Conference XXXI on Laboratory Monitoring of Anticoagulant Therapy. Archives of Pathology & Laboratory Medicine, 122, 782-798.
[26]
Kitchen, S. and McCraw, A. (2000) Diagnosis of Hemophilia and Other Bleeding Disorders. 150.
[27]
Harris, L.F. and Killard, A.J. (2012) Heparin Monitoring: From Blood Tube to Microfluidic Device. In: Piyathilake, D.E. and Liang, R., Eds., Heparin, Properties, Uses and Side Effects, Nova Science Publishers, Hauppauge, NY.
[28]
Von Lode, P. (2005) Point-of-Care Immunotesting: Approaching the Analytical Performance of Central Laboratory Methods. Clinical Biochemistry, 38, 591-606.
https://doi.org/10.1016/j.clinbiochem.2005.03.008
[29]
St John, A. and Price, C.P. (2014) Existing and Emerging Technologies for Point-of-Care Testing. The Clinical Biochemist Reviews, 35, 155-167.
[30]
Jaryno, S., et al. (2000) Validation of a New Whole Blood Coagulation Monitoring System. The Journal of the American Society of Extra-Corporeal Technology, 34, 271-275.
[31]
Harris, L.F., Castro-López, V. and Killard, A.J. (2013) Coagulation Monitoring Devices: Past, Present, and Future at the Point of Care. TrAC Trends in Analytical Chemistry, 50, 85-95. https://doi.org/10.1016/j.trac.2013.05.009
[32]
Joshi, K. H., et al. (2016) Detection of Heparin Level in Blood Using Electromagnetic Wave Spectroscopy. 2016 9th International Conference on Developments in eSystems Engineering (DeSE), Liverpool, 31 August-2 September 2016, 329-334.
https://doi.org/10.1109/DeSE.2016.51
[33]
Lewandrowski, E.L., et al. (2011) Clinical Evaluation of the i-STAT Kaolin Activated Clotting Time (ACT) Test in the Different Clinical Settings in a Large Academic Urban Medical Center: Comparison with the Medtronic ACT Plus. American Journal of Clinical Pathology, 135, 741-748.
https://doi.org/10.1309/AJCPSF8ASGONNQM6
Ranucci, M., Laddomada, T., Ranucci, M. and Baryshnikova, E. (2014) Blood Viscosity during Coagulation at Different Shear Rates. Physiological Reports, 2, e12065.
https://doi.org/10.14814/phy2.12065
[36]
Jain, A., et al. (2016) A Shear Gradient-Activated Microfluidic Device for Automated Monitoring of Whole blood Haemostasis and Platelet Function. Nature Communications, 7, Article No. 10176. https://doi.org/10.1038/ncomms10176
[37]
Hegener, M.A., Li, H., Han, D., Steckl, A.J. and Pauletti, G.M. (2017) Point-of-Care Coagulation Monitoring: First Clinical Experience Using a Paper-Based Lateral Flow Diagnostic Device. Biomedical Microdevices, 19, Article No. 64.
https://doi.org/10.1007/s10544-017-0206-z
[38]
Harris, L.F. and Killard, A.J. (2018) Microfluidics in Coagulation Monitoring Devices: A Mini Review. Analytical Methods, 10, 3714-3719.
https://doi.org/10.1039/C8AY01230J
[39]
Govindarajan, V., et al. (2018) Impact of Tissue Factor Localization on Blood Clot Structure and Resistance under Venous Shear. Biophysical Journal, 114, 978-991.
https://doi.org/10.1016/j.bpj.2017.12.034
