A Comparative Study on Safety and Efficacy of Caudal, Thoracic Epidural and Intra Venous Analgesia in Paediatric Cardiac Surgery: A Double Blind Randomised Trial
Introduction:Regional anaesthesia combined
with general anaesthesia reduces stress response to
surgery, duration of ventilation, intensive care unit (ICU) stay and promotes early recovery. Studies on
thoracic epidural, caudal analgesia along with general anaesthesia (GA) in paediatric cardiac surgery are
limited hence we aimed to compare efficacy
and safety of caudal, thoracic epidural and intravenous analgesia in
paediatric cardiac surgery. Methodology: This study was conducted in the
Department of Anaesthesiology in a tertiary care teaching hospital in southern
India from February 2019 to December 2019. 90 children were randomised into
group A, group B, group C. Children in group A received caudal analgesia along
with GA. Group B children received thoracic epidural along with GA. Group C
patients received intravenous analgesia along with GA. Rescue analgesia 1 mcg/kg
fentanyl given in all 3 groups if pain
score is more than 4. Primary outcome assessed was post-op pain scores. Secondary outcome assessed
was duration of ventilation, duration of intensive care unit stay. Results: All patients were comparable in terms of age, sex, weight, mean RACHS score, baseline heart rate and blood pressure. Pain
scores were significantly lower in
thoracic epidural group compared to other two grou ps. Duration of
ventilation was lower in thoracic epidural group (91.17± 43.85) minutes and caudal (199.6 ±
References
[1]
Hammer, G.B. (1999) Regional Anesthesia for Pediatric Cardiac Surgery. Journal of Cardiothoracic and Vascular Anesthesia, 13, 210-213. https://doi.org/10.1016/S1053-0770(99)90091-5
[2]
Roberts, S. (2018) Regional Anesthesia in Pediatric Patients: General Considerations. NYSORA.
[3]
Rao, T.L. and El-Etr, A.A. (1981) Anticoagulation Following Placement of Epidural and Subarachnoid Catheters: An Evaluation of Neurologic Sequelae. Anesthesiology, 55, 618-620. https://doi.org/10.1097/00000542-198155060-00002
[4]
Walker, B.J., Long, J.B., Sathyamoorthy, M., Wright, C. and Rosenbloom, J. (2018) Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network. Anesthesiology, 129, 721-732. https://doi.org/10.1097/ALN.0000000000002372
[5]
Peterson, K.L., DeCampli, W.M., Pike, N.A., Robbins, R.C. and Reitz, B.A. (2000) A Report of Two Hundred Twenty Cases of Regional Anesthesia in Pediatric Cardiac Surgery. Anesthesia & Analgesia, 90, 1014. https://doi.org/10.1097/00000539-200005000-00002
[6]
Iwasaki, M., Edmondson, M., Sakamoto, A. and Ma, D. (2015) Anesthesia, Surgical Stress, and “Long-Term” Outcomes. Acta Anaesthesiologica Taiwanica, 53, 99-104. https://doi.org/10.1016/j.aat.2015.07.002
[7]
Novak-Jankovič, V. and Paver-Eržen, V. (2002) How Can Anesthetists Modify Stress Response during Perioperative Period? In: Gullo, A., Ed., Anaesthesia, Pain, Intensive Care and Emergency Medicine, Springer, Milan, 1025-1034. https://doi.org/10.1007/978-88-470-2099-3_89
[8]
Hammer, G.B., Ngo, K. and Macario, A. (2000) A Retrospective Examination of Regional plus General Anesthesia in Children Undergoing Open Heart Surgery. Anesthesia & Analgesia, 90, 1020-1024. https://doi.org/10.1097/00000539-200005000-00004
[9]
De Pinto, M., Dagal, A., O’Donnell, B., Stogicza, A., Chiu, S. and Edwards, W.T. (2015) Regional Anesthesia for Management of Acute Pain in the Intensive Care Unit. International Journal of Critical Illness and Injury Science, 5, 138-143. https://doi.org/10.4103/2229-5151.164917
[10]
Nguyen, K.N., Byrd, H.S. and Tan, J.M. (2016) Caudal Analgesia and Cardiothoracic Surgery: A Look at Postoperative Pain Scores in a Pediatric Population. Paediatric Anaesthesia, 26, 1060-1063. https://doi.org/10.1111/pan.12990
[11]
Samantaray, D.J., Trehan, M., Chowdhry, V. and Reedy, S. (2019) Comparison of Hemodynamic Response and Postoperative Pain Score between General Anaesthesia with Intravenous Analgesia versus General Anesthesia with Caudal Analgesia in Pediatric Patients Undergoing Open-Heart Surgery. Annals of Cardiac Anaesthesia, 22, 35. https://doi.org/10.4103/aca.ACA_215_17
[12]
Vilà, R., Potau, N., Garcia, M., Acosta, D. and Miguel, E. (2000) Thoracic Epidural Anaesthesia in Paediatric Open Cardiac Surgery. Our Experience with Ropivacaine-Morphine. European Journal of Anaesthesiology, 17, 150. https://doi.org/10.1097/00003643-200000002-00490
[13]
Sharma, V.K. (2013) Is Caudal Dexmedetomidine in Pediatric Cardiac Surgery a Novel Idea? Annals of Cardiac Anaesthesia, 16, 115-116.
[14]
Baker, J.E. and Mazer, C.D. (2008) Anticoagulation and Regional Anesthesia in Cardiac Surgery: Safety Considerations. Techniques in Regional Anesthesia and Pain Management, 12, 17-25. https://doi.org/10.1053/j.trap.2007.10.003
[15]
Horlocker, T.T., Vandermeuelen, E., Kopp, S.L., Gogarten, W., Leffert, L.R. and Benzon, H.T. (2018) Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition). Regional Anesthesia & Pain Medicine, 43, 263-309. https://doi.org/10.1097/AAP.0000000000000763
[16]
Abd-Elshafy, S.K., Abdalla, E., Ali, M. and Mohamed, H. (2015) Caudal Neostigmine and Bupivacaine Facilitates Early Extubation and Provides Prolonged Postoperative Analgesia in Children Undergoing Open Heart Surgery. Anesthesia and Clinical Research, 6, 1-6.
[17]
Nasr, D.A. and Abdelhamid, H.M. (2013) The Efficacy of Caudal Dexmedetomidine on Stress Response and Postoperative Pain in Pediatric Cardiac Surgery. Annals of Cardiac Anaesthesia, 16, 109. https://doi.org/10.4103/0971-9784.109744
[18]
Rosen, K.R. and Rosen, D.A. (1989) Caudal Epidural Morphine for Control of Pain Following Open Heart Surgery in Children. Anesthesiology, 70, 418-421. https://doi.org/10.1097/00000542-198903000-00009
[19]
Mittnacht, A.J.C., Thanjan, M., Srivastava, S., Joashi, U., Bodian, C., Hossain, S., et al. (2008) Extubation in the Operating Room after Congenital Heart Surgery in Children. The Journal of Thoracic and Cardiovascular Surgery, 136, 88-93. https://doi.org/10.1016/j.jtcvs.2007.11.042
[20]
Leyvi, G., Taylor, D.G., Reith, E., Stock, A., Crooke, G. and Wasnick, J.D. (2005) Caudal Anesthesia in Pediatric Cardiac Surgery: Does It Affect Outcome? Journal of Cardiothoracic and Vascular Anesthesia, 19, 734-738. https://doi.org/10.1053/j.jvca.2005.01.041
[21]
Makhija, N., Kiran, U., Choudhary, S., Lakshmy, R., Das, S. and Sendasgupta, C. (2009) Caudal Epidural Sufentanil and Bupivacaine Decreases Stress Response in Paediatric Cardiac Surgery. Annals of Cardiac Anaesthesia, 12, 27. https://doi.org/10.4103/0971-9784.45010
[22]
Duncan, H.P., Cloote, A., Weir, P.M., Jenkins, I., Murphy, P.J., Pawade, A.K., et al. (2000) Reducing Stress Responses in the Pre-Bypass Phase of Open Heart Surgery in Infants and Young Children: A Comparison of Different Fentanyl Doses. British Journal of Anaesthesia, 84, 556-564. https://doi.org/10.1093/bja/84.5.556
[23]
Suresh, S., Long, J., Birmingham, P.K. and De Oliveira, G.S. (2015) Are Caudal Blocks for Pain Control Safe in Children? An Analysis of 18,650 Caudal Blocks from the Pediatric Regional Anesthesia Network (PRAN) Database. Anesthesia & Analgesia, 120, 151-156. https://doi.org/10.1213/ANE.0000000000000446
[24]
Rosen, D.A., Rosen, K.R. and Hammer, G.B. (2002) Pro: Regional Anesthesia Is an Important Component of the Anesthetic Technique for Pediatric Patients Undergoing Cardiac Surgical Procedures. Journal of Cardiothoracic and Vascular Anesthesia, 16, 374-378. https://doi.org/10.1053/jcan.2002.124152