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运动干预AD的靶点——肌肉因子鸢尾素
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Abstract:
阿尔茨海默病(AD)是一种多发于老年人的进行性记忆功能障碍，主要的病理特征为脑中β淀粉样蛋白(Aβ)积聚形成的老年斑，以及过度磷酸化的tau构成是神经原纤维缠结。鸢尾素(Irisin)是与运动密切相关的一种肌动蛋白，最近的研究表明，鸢尾素与中枢神经系统密切相关，鸢尾素能减少Aβ生成，促进神经发生，抑制神经炎症和减轻氧化应激，说明鸢尾素可能是治疗AD的新机制。运动能预防和改善AD，但其分子机制尚不明晰，综合近期研究，运动防治AD的分子机制与鸢尾素有关，运动能增加正常大鼠和AD大鼠脑中和血清鸢尾素水平，并改善AD病理表现，因此鸢尾素是介导运动干预AD的新靶点。
Alzheimer’s disease (AD) is a type of progressive memory dysfunction that is common in the elderly. The main pathological features are senile plaques formed by the accumulation of beta amyloid (Aβ) in the brain, and tau, which is over-phosphorylated, is a nerve tangled fibrils. Irisin is an actin that is closely related to exercise. Recent studies have shown that irisin is closely related to the central nervous system. Irisin can reduce Aβ production, promote neurogenesis, inhibit neuroinflammation and reduce oxidative stress. Indicating that irisin may be a new mechanism for treating AD. Exercise can prevent and improve AD, but its molecular mechanism is not clear. Comprehensive recent studies have shown that the molecular mechanism of exercise to prevent AD is related to irisin. Exercise can increase normal and serum irisin levels in the brain of normal rats and AD rats, and improve Pathological manifestations of AD, so irisin is a new target for mediating exercise intervention in AD.
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