长链非编码RNA RMRP RNA促成骨分化的研究进展
Research Advances of the Long Non-Coding RNA RMRP RNA Promoting the Osteoblastic Differentiation

DOI: 10.12677/BIPHY.2019.73005, PP. 49-56

Keywords: RMRP RNA，成骨发育，RNase MRP，RMRP-S1/2，底物
RMRP RNA, Osteoblastic Differentiation, RNase MRP, RMRP-S1/2, Substrates

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Abstract:

RMRP RNA是一个长链非编码RNA。RMRP RNA不同位点的突变,包括转录区和调控区的突变会导致几种常染色体隐性的骨骼发育不良，其中之一是CHH。RMRP RNA可以通过形成核酸内切酶RNase MRP发挥功能，或者通过Dicer酶依赖途径产生2种microRNA，即RMRP-S1和RMRP-S2，调控细胞。与RMRP RNA研究相关最多的方面是关于癌症的发生，在成骨分化中研究很少。该综述从成骨发育过程，RNase MRP、RMRP-S1和RMRP-S2的底物与成骨发育的可能的关系几个方面进行阐述，为后续研究RMRP RNA在成骨发育中的分子机制提供一个参考。
RMRP RNA is a long non-coding RNA. Mutations in the different sites, including regulation regions and transcription regions, of RMRP RNA are sources of some autosomal recessive skeletal dysplasia. One of them is CHH. RMRP RNA can form a endonuclease RNase MRP to exert it’s function. Or it produce two microRNAs (RMRP-S1 and RMRP-S2) through the Dicer enzyme-dependent pathway to regulate cells. RMRP RNA is most involved in the research of cancer. It is farely understood that how RMRP RNA is engaged in the differentiation of osteoblast. In this review, we will state the process of osteoblast differentiation and the relationship between substrates of RNase MRP, RMRP-S1 and RMRP-S2 and the osteoblastic differentiation to promote the follow-up study of the molecular mechanism of RMRP RNA in the osteoblastic differentiation.

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