全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

角膜上皮干细胞的功能定位及其与眼表疾病的关系
The Function and Localization of Corneal Epithelial Stem Cells and Its Relationship with Ocular Surface Diseases

DOI: 10.12677/HJO.2019.84021, PP. 127-133

Keywords: 角膜上皮干细胞，角膜缘干细胞，眼表疾病，角膜缘干细胞功能障碍
Corneal Epithelial Stem Cells, Limbal Stem Cells, Ocular Surface Diseases, Limbal Stem Cell Deficiency

Full-Text   Cite this paper   Add to My Lib

Abstract:

角膜上皮干细胞具有更新修复角膜上皮的重要功能，其定位于角膜缘受到广泛认可，但有越来越多的研究表明，不管是通过特异性标识物定位还是功能定位，都无法证实角膜上皮干细胞仅位于角膜缘，角膜缘干细胞在角膜上皮更新修复方面起到的作用有限。本文通过对角膜上皮干细胞研究的不同观点和证据的阐述，对近年来有关角膜上皮干细胞的功能定位及其与眼表疾病的关系研究作一综述。
Corneal epithelial stem cells (CESCs) play an important role in repairing corneal epithelium. Their localization in limbus corneae has been widely recognized. However, more and more studies show that no matter through specific markers or functional localization, it cannot be confirmed that corneal epithelial stem cells are located only in limbus, and limbus stem cells play a limited role in renewal and repair of corneal epithelial. This article reviews the different viewpoints and evidences of corneal epithelial stem cells research, and summarizes the recent studies about the function and the localization of corneal epithelial stem cells and the relationship with ocular surface diseases in recent years.

References

[1]  赵堪兴, 杨培增. 眼科学[M]. 第8版. 北京: 人民卫生出版社, 2013: 90-92.
[2]  安克. 胚胎干细胞定向诱导分化为心肌细胞进展[J]. 中国优生与遗传杂志, 2018, 16(12): 3-4.
[3]  Schermer, A., Galvin, S. and Sun, T.T. (1986) Differentiation-Related Expression of a Major 64k Corneal Epithelial Stem Cells. The Journal of Cell Biology, 103, 49-62.
https://doi.org/10.1083/jcb.103.1.49
[4]  Dua, H.S., Miri, A., Alomar, T., Yeung, A.M. and Said, D.G. (2009) The Role of Limbal Stem Cells in Corneal Epithelial Maintenance: Testing the Dogma. Ophthalmology, 116, 856-863.
https://doi.org/10.1016/j.ophtha.2008.12.017
[5]  Kawashima, M., Kawakita, T., Yoshida, S., et al. (2009) Nueleostemin as a Possible Progenitor Marker of Corneal Epithelial Cells. Molecular Vision, 15, 1162-1168.
[6]  Umemoto, T., Yamato, M., Nishida, K., et al. (2005) Rat Limhal Epithelial Side Population Cells Exhibit a Distinct Expression of Stem Cell Markers that Are Lacking in Side Population Cells from the Central Cornea. FEBS Letters, 579, 6569-6574.
https://doi.org/10.1016/j.febslet.2005.10.047
[7]  Lyngholm, M., Vorum, H., Nielsen, K., et al. (2008) Differences in the Protein Expression in Limbal versus Central Human Corneal Epithelium—A Search For Stem Cell Markers. Experimental Eye Research, 87, 96-105.
https://doi.org/10.1016/j.exer.2008.05.001
[8]  Schlotzer-schrehardt, U. and Kruse, F.E. (2005) Identification and Characterization of Limbal Stem Cells. Experimental Eye Research, 81, 247-264.
https://doi.org/10.1016/j.exer.2005.02.016
[9]  刘先宁, 吴浩, 朱秀萍. 角膜上皮干细胞缺失动物模型的方法研究[J]. 国际眼科杂志, 2009, 9(8): 1583-1584.
[10]  Huang, A.J. and Tseng, S.C. (1991) Corneal Epithelial Wound Healing in the Absence of Limbal Epithelium. Investigative Ophthalmology & Visual Science, 32, 96-105.
[11]  Majo, F., Rochat, A., Nicolas, M., et al. (2008) Oligopotent Stem Cells Are Distributed throughout the Mammalian Ocular Surface. Nature, 456, 250-254.
https://doi.org/10.1038/nature07406
[12]  Chang, C.Y., Green, C.R., Mcgheen, C.N., et al. (2008) Acute Wound Healing in the Human Central Corneal Epithelium Appears to Be Independent of Limbal Stem Cell Influence. Investigative Ophthalmology & Visual Science, 49, 5279-5286.
https://doi.org/10.1167/iovs.07-1260
[13]  周庆军, 谢立信. 干细胞移植修复眼表损伤的研究进展[J]. 中华眼科杂志, 2009, 45(7): 658-661.
[14]  Tanioka, H., Kawasaki, S., Yamusaki, K., et al. (2006) Establishment of a Cultivated Human Conjunctival Epithelium as an Alternative Tissue Source for Autologous Corneal Epithelial Transplantation. Investigative Ophthalmology & Visual Science, 47, 3820-3827.
https://doi.org/10.1167/iovs.06-0293
[15]  Hori, J., Ohara, K., Sakuragawa, N., et al. (2002) Pro-Inflammatory Effect of Amniotic Epithelial Allografis on Orthotopic Corneal Allografts. Investigative Ophthalmology & Visual Science, 43, 2254.
[16]  Nakamura, T., Inatomi, T., Sotozono, C., et al. (2004) Transplantation of Cultivated Autologous Oral Mucosal Epithelial Cells in Patients with Severe Ocular Surface Disorders. British Journal of Ophthalmology, 88, 1280-1284.
https://doi.org/10.1136/bjo.2003.038497
[17]  Bruste, O., Jones, K.N., Learish, R.D., Karram, K., et al. (1999) Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants. Science, 285, 754-756.
https://doi.org/10.1126/science.285.5428.754
[18]  Dreyfus, P.A., Chretien, F., Chazaud, B., et al. (2004) Adult of Bone Marrow-Derived Stem Cells in Muscle Connective Tissue and Satellite Cell Niche. American Journal of Ophthalmology, 164, 773-779.
https://doi.org/10.1016/S0002-9440(10)63165-3
[19]  柯红琴, 刘磊, 栗静, 等. 兔全角膜缘干细胞缺乏模型的构建和鉴定[J]. 中华实验眼科杂志, 2013, 31(2): 151-155.
[20]  赵堪兴, 杨培增. 眼科学[M]. 第8版. 北京: 人民卫生出版社, 2013: 113-114.
[21]  刘祖国. 眼表疾病学[M]. 北京: 人民卫生出版社, 2003: 355-356.
[22]  王丹, 汪锐, 张启明, 等. 三种手术方式治疗翼状胬肉的临床观察[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 94-95.
[23]  姚小琪. 翼状胬肉单纯切除与联合角膜缘干细胞移植的疗效观察[J]. 包头医学院学报, 2015, 31(10): 69-70.
[24]  Dua, H. (1998) The Conjunctiva in Corneal Epithelial Wound Healing. British Journal of Ophthalmology, 82, 1407-1411.
https://doi.org/10.1136/bjo.82.12.1407
[25]  Anderson, D., Ellies, P., Pires, R.T. and Tseng, S.C.G. (200l) Amnoitic Membrane Transplantation for Partial Limbal Stem Cell Deficiency. British Journal of Ophthalmology, 85, 567-575.
https://doi.org/10.1136/bjo.85.5.567
[26]  Shimmura, S. and Tsubota, K. (2008) Surgical Treatment of Limbal Stem Cells Deficiency: Are We Really Transplanting Stem Cells? American Journal of Ophthalmology, 146, 154-155.
https://doi.org/10.1016/j.ajo.2008.04.025

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133