利用响应面法优化五指毛桃复方制剂中五指毛桃的提取工艺条件。在单因素试验研究的基础上，应用Design Expert 8.0.6建立数学模型，以五指毛桃含量为响应值，进行三因素三水平的响应面分析。结果表明，利用连续式提取分离浓缩器提取五指毛桃复方制剂中补骨脂素的最佳工艺为温度43℃、料液比为51:1 mL:g、压力36 Mpa。
The optimal conditions of extraction of psoralen were explored from Compound Radix Ficus hirta Vahl preparations by response surface methodology. Based on one-factor-at-a-time experiments, solid to liquid ratio, temperature, and pressure were determined as independent variables. Response surface methodology (RSM) based on a three-level, three-variable Box-Behnken design was applied to study the main effect factors of the extraction process of psoralen from Compound Radix Ficus hirta Vahl preparations, and establish the corresponding mathematical model, then response surface analysis (RSA) was conducted with the psoralen in the preparation as responsiveness. The optimal extraction conditions were obtained as follows: the temperature 43？C, the liquid to solid ratio 51:1 mL:g, pressure 36 Mpa.
