Introduction: We report an unusual case of squamous cell carcinoma on a verrucous lichen of chronic evolution taken in charge in Borgou/Alibori UHC in Parakou (Bénin). Observation: A 75-year old Beninese woman with a history of portal hypertension post-viral cirrhosis C treated with negative viral load, had consulted for a large chronic ulceration of the right foot back. The beginning of the symptomatology would go back to about 30 years, marked by lichenified, pruriginous popular lesions; these lesions would initially be treated as eczema and then mycosis by health personnel not specialised in dermatology and multitreated with unspecified topicals. General state was altered. In addition to ulceration, the dermatological examination found plates of hyperpigmented lichen lesion, homogeneous and well limited bilateral and symmetrical topography on the pelvic limbs making difficult to walk. Anatomopathological examination of the biopsy sample straddling the ulceration and its edges suggested a hypertrophic cutaneous lichen associated with keratinizing, infiltrating epidermal carcinoma. The chest-abdominal-pelvic scan showed no metastasis. A complete amputation of the right leg and knee was performed after a psychological interview. The follow-up was marked by an over-infection of the amputation stump by Escherichia coli, which was successfully treated. Healed, she is waiting for orthopedic equipment and possible chemotherapy. Conclusion: This clinical case indicates the need for adequate management of certain potentially precancerous dermatoses, in order to limit the progression to carcinogenic transformation.
References
[1]
Le Cleach, L. and Chosidow, O. (2012) Clinical Practice. Lichen Planus. The New England Journal of Medicine, 366, 723-732. https://doi.org/10.1056/NEJMcp1103641
[2]
Strak, S.K., Al-Hamdi, K.I. and Alabbood, M.H. (2015) A Study of Lichen Planus and Its Association with Hepatitis C Infection. Journal of Taibah University Medical Sciences, 10, 222-226. https://doi.org/10.1016/j.jtumed.2014.08.001
[3]
Fitzpatrick, S.G., Hirsch, S.A. and Gordon, S.C. (2014) The Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Systematic Review. The Journal of the American Dental Association, 145, 45-56. https://doi.org/10.14219/jada.2013.10
[4]
Ali, N.M., Bhat, R. and Rao, S.B. (2015) Concurrent Presentation of Erythrodermic Lichen Planus and Squamous Cell Carcinoma: Coincidence or Malignant Transformation? Indian Journal of Dermatology, 60, 457-460. https://doi.org/10.4103/0019-5154.164355
[5]
Sigurgeirsson, B. and Lindelöf, B. (1991) Lichen Planus and Malignancy. An Epidemiologic Study of 2071 Patients and a Review of Literature. Archives of Dermatology, 127, 1684-1688. https://doi.org/10.1001/archderm.1991.01680100084009
[6]
Raharolahy, O., Andrianarison, M., Ranaivo, I.M., Sendrasoa, F.A., Ramarozatovo, L.S. and Rapelanoro Rabenja, F. (2016) Manifestations cutanées inhabituelles au cours de l’hépatite virale C. Annales de Dermatologie et de Vénéréologie, 143, 15-16. https://doi.org/10.1016/S0151-9638(16)30117-X
[7]
Kchir, H., Dabbedi, H., Mahfoudhi, M., Essid, M., Ben Jeddi, H., Chaabouni, H., et al. (2015) Manifestations dermatologiques associées au virus de l’hépatite C. La Revue de Médecine Interne, 36, 102. https://doi.org/10.1016/j.revmed.2015.03.076
[8]
Dupond, A.S. (2014) Lichen plan et dermatoses lichénoïdes. Traité de l’EMC, 9, 1-11.
[9]
Burton, K.A., Ashack, K.A. and Khachemoune, A. (2016) Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease. American Journal of Clinical Dermatology, 17, 491-508. https://doi.org/10.1007/s40257-016-0207-3
[10]
Farasat, S., Yu, S.S., Neel, V.A., Nehal, K.S., Lardaro, T., Mihm, M.C., et al. (2011) A New American Joint Committee on Cancer Staging System for Cutaneous Squamous Cell Carcinoma: Creation and Rational for Inclusion of Tumor Characteristics. Journal of the American Academy of Dermatology, 64, 1051-1059. https://doi.org/10.1016/j.jaad.2010.08.033
[11]
Yao, M., Brummer, G., Acevedo, D. and Cheng, N. (2016) Cytokine Regulation of Metastasis and Tumorigenicity. Advances in Cancer Research, 132, 265-367. https://doi.org/10.1016/bs.acr.2016.05.005
[12]
Reich-Schupke, S., Doerler, M., Wollina, U., Dissemond, J., Horn, T., Strölin, A., et al. (2015) Squamous Cell Carcinomas in Chronic Venous Leg Ulcers. Data of the German Marjolin Registry and Review. Journal der Deutschen Dermatologischen Gesellschaft, 13, 1006-1013. https://doi.org/10.1111/ddg.12649
[13]
Oshi, R. and Durve, U. (2007) Squamous Cell Carcinoma in Hypertrophic Lichen Planus. Indian Journal of Dermatology, Venereology and Leprology, 13, 54-55. https://doi.org/10.4103/0378-6323.30658
[14]
Olawoye, O.A., Michael, A.I. and Oluwasola, O.A. (2013) Marjolin’s Ulcer Arising from Cutaneous Lichen Planus. East and Central African Journal of Surgery, 18, 164-167.
[15]
Shetty, R., Lamba, S., Gulur, A., Patel, S. and Kumar Gupta, A. (2013) Carcinoma in Cutaneous Lichen Planus. Nasza Dermatologia Online. Our Dermatology Online, 4, 75-77. https://doi.org/10.7241/ourd.20131.14
[16]
Thakur, B.K., Verma, S. and Raphael, V. (2015) Verrucous Carcinoma Developing in a Long Standing Case of Ulcerative Lichen Planus of Sole: A Rare Case Report. Journal of the European Academy of Dermatology and Venereology, 29, 399-401. https://doi.org/10.1111/jdv.12406
[17]
Tong, L.X., Weinstock, M.J., Drews, R., Sheikine, Y. and Kim, C.C. (2015) Widely Metastatic Squamous Cell Carcinoma Originating from Malignant Transformation of Hypertrophic Lichen Planus in a 24-Year-Old Woman: Case Report and Review of the Literature. Pediatric Dermatology, 32, 98-101. https://doi.org/10.1111/pde.12549
[18]
Alfonso, J.H., Martinsen, J.I., Pukkala, E., Weiderpass, E., Tryggvadottir, L., Nordby, K.-C., et al. (2016) Occupation and Relative Risk of Cutaneous Squamous Cell Carcinoma: A 45-Year Follow-Up Study in 4 Nordic Countries. Journal of the American Academy of Dermatology, 75, 548-555. https://doi.org/10.1016/j.jaad.2016.03.033
[19]
Dervault, A.M., Secretan, B., Guinot, C., Bazex, J., Donadieu, J., Doré, et al. (2005) Ultraviolets-Etats des connaissances sur l’exposition et les risques sanitaires. Afsse InVs Afssaps, 44-45.
[20]
Bonerandi, J.J., Beauvillain, C., Caquant, L., Chassagne, J.F., Chaussade, V., Clavère, P., et al. (2011) Guidelines for the Diagnosis and Treatment of Cutaneous Squamous Cell Carcinoma and Precursor Lesions. Journal of the European Academy of Dermatology and Venereology, 25, 1-51. https://doi.org/10.1111/j.1468-3083.2011.04296.x
