Background: Intracoronary thrombus burden is associated with some adverse events and poor prognosis in patients with Acute Coronary Syndrome.Identifying predictors of the intracoronary thrombus burden may contribute to the management of Acute Coronary Syndrome.Objective: To assess the correlation between the Monocyte to HDL Cholesterol ratio with thrombus burden in patients with Acute Coronary Syndrome.Patients and Methods: 138 patients with ACS who were admitted to CCU department in National Heart Institute Cairoand Menoufia University Hospitals, Menoufia, underwent primary percutaneous coronary intervention (PCI).Angiographic thrombus burden was classified based on thrombolysisin myocardial infarction (TIMI) thrombus grades.The patients were grouped into 2 categories of low thrombus burden (grades 0-3) (49.7%) andhigh thrombus burden (grades 4 and 5) (50.3%).Results: On analysis we found that the MHR was
References
[1]
Sianos, G., Papafaklis, M.I., Daemen, J., et al. (2007) Angiographic Stentthrombosis after Routine Use of Drug-Eluting Stents in ST-Segment Elevation Myocardial Infarction: The Importance of Thrombus Burden. Journal of the American College of Cardiology, 50, 573-583. https://doi.org/10.1016/j.jacc.2007.04.059
[2]
Sianos, G., Papafaklis, M.I. and Serruys, P.W. (2010) Angiographic Thrombus Burden Classification in Patients with ST-Segment Elevation Myocardial Infarction Treated with Percutaneous Coronary Intervention. Journal of Invasive Cardiology, 22, 6B-14B.
[3]
Singh, M., Berger, P.B., Ting, H.H., et al. (2001) Influence of Coronary Thrombus on Outcome of Percutaneous Coronary Angioplasty in the Current Era (the Mayo Clinic Experience). American Journal of Cardiology, 88, 1091-1096.
https://doi.org/10.1016/S0002-9149(01)02040-9
[4]
Tanboga, I.H., Topcu, S., Aksakal, E., Kalkan, K., Sevimli, S. and Acikel, M. (2014) Determinants of Angiographic Thrombus Burden in Patients with ST-Segment Elevation Myocardial Infarction. Clinical and Applied Thrombosis/Hemostasis, 20, 716- 722. https://doi.org/10.1177/1076029613483169
[5]
Hamur, H., Duman, H., Bakirci, E.M., et al. (2016) Bilirubin Levels and Thrombus Burden in Patients with ST-Segment Elevation Myocardialinfarction. Angiology, 67, 565-570. https://doi.org/10.1177/0003319715603899
[6]
Gibson, C.M., de Lemos, J.A., Murphy, S.A., et al. (2001) Combination Therapy with Abciximab Reduces Angiographically Evident Thrombus in Acute Myocardial Infarction: A TIMI 14 Substudy. Circulation, 103, 2550-2554.
https://doi.org/10.1161/01.CIR.103.21.2550
[7]
Akpek, M., Elcik, D., Kalay, N., et al. (2013) The Prognostic Value of Serum Gamma Glutamyl Transferase Activity on Admission in Patients with STEMI Undergoing Primary PCI. Angiology, 63, 579-585. https://doi.org/10.1177/0003319711431880
[8]
Ghattas, A., Griffiths, H.R., Devitt, A., et al. (2013) Monocytes in Coronary Artery Disease and Atherosclerosis: Where Are We Now? Journal of the American College of Cardiology, 62, 1541-1551. https://doi.org/10.1016/j.jacc.2013.07.043
[9]
Kundi, H., Kiziltunc, E., Cetin, M., et al. (2016) Association of Monocyte/HDL-C Ratio with SYNTAX Scores in Patients with Stable Coronary Artery Disease. Herz, 41, 523-529. https://doi.org/10.1007/s00059-015-4393-1
[10]
Nozawa, N., Hibi, K., Endo, M., Sugano, T., Ebina, T., Kosuge, M., et al. (2010) Association between Circulating Monocytes and Coronary Plaque Progression in Patients with Acute Myocardial Infarction. Circulation Journal, 74, 1384-1391.
https://doi.org/10.1253/circj.CJ-09-0779
[11]
Antman, E.M., Wiviott, S.D., Murphy, S.A., et al. (2008) Early and Late Benefits of Prasugrel in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: A TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction) Analysis. Journal of the American College of Cardiology, 51, 2028-2033.
[12]
Cetin, M.S., Ozcan Cetin, E.H., Kalender, E., Aydin, S., Topaloglu, S., Kisacik, H.L. and Temizhan, A. (2016) Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome. Heart, Lung and Circulation, 25, 1077-1086.
[13]
Davidson, W.S., Silva, R.A., Chantepie, S., Lagor, W.R., Chapman, M.J. and Kontush, A. (2009) Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters: Relevance to Antioxidative Function. Arteriosclerosis, Thrombosis, and Vascular Biology, 29, 870-876.
https://doi.org/10.1161/ATVBAHA.109.186031