Objective:To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan
Province. Methods:Essen trauma inventory(ETI), clinician
administered post-traumatic stress disorders scale,(CAPS), tower of Hanoi
(TOH), wsiconsin card sorting test (WCST), trail making test(TMT) and wechsler
adult intelligence scale revised China(WAIS-RC) were used to
investigate patients with PTSD and healthy volunteers (control group). PCR and
PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results:The ETI score, total PTSD score and TMT time of Li
nationality patients with PTSD were significantly higher than those of Han
nationality patients with PTSD, and the IQ of comprehension and operation in
WAIS-RC was significantly lower than that of Han nationality patients with PTSD
(P < 0.05). The ETI score,
total PTSD score and TMT time of 5-HTTLPR genotype in Li nationality and Han nationality patients with PTSD were
significantly higher than those of LL genotype, and the perception, calculation
and block diagram in WAIS-RC were significantly lower than those of LL genotype
patients (P < 0.05). Conclusions:The SS genotype can increase the risk of PTSD in Li
nationality and Han nationality people in Hainan. LL genotype is associated
with PTSD of Li and Han nationalities in Hainan, and is an important protective
factor for PTSD of Li and Han nationalities in Hainan.
References
[1]
Roth, T.L., Zoladz, P.R., Sweatt, J.D. and Diamond, D.M. (2011) Epigenetic Modification of Hippocampal Bdnf DNA in Adult Rats in an Animal Model of Post-Traumatic Stress Disorder. Journal of Psychiatric Research, 45, 919-926.
https://doi.org/10.1016/j.jpsychires.2011.01.013
[2]
Chapman, C., Mills, K., Slade, T., et al. (2012) Remission from Post-Traumatic Stress Disorder in the General Population. Psychological Medicine, 42, 1695-1703.
https://doi.org/10.1017/S0033291711002856
[3]
Robinson, B.L. and Shergill, S.S. (2011) Imaging in Posttraumatic Stress Disorder. Current Opinion in Psychiatry, 24, 29-33.
https://doi.org/10.1097/YCO.0b013e3283413519
[4]
Walsh, K., Uddin, M., Soliven, R., Wildman, D.E. and Bradley, B. (2014) Associations between the SS Variant of 5-HTTLPR and PTSD among Adults with Histories of Childhood Emotional Abuse: Results from Two African American Independent Samples. Journal of Affective Disorders, 161, 91-96.
https://doi.org/10.1016/j.jad.2014.02.043
[5]
Andero, R., Brothers, S.P., Jovanovic, T., et al. (2013) Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD. Science Translational Medicine, 5, 188ra73. https://doi.org/10.1126/scitranslmed.3005656
[6]
Banerjee, S.B., Morrison, F.G. and Ressler, K.J. (2017) Genetic Approaches for the Study of PTSD: Advances and Challenges. Neuroscience Letters, 649, 139-146.
https://doi.org/10.1016/j.neulet.2017.02.058
[7]
Forresi, B., Caffo, E. and Battaglia, M. (2015) Gene Environment Interplays: Why PTSD Makes a Good Case for Gene-Environment Interaction Studies and How Adding a Developmental Approach Can Help. In: Martin, C., Preedy, V. and Patel, V., Eds., Comprehensive Guide to Post-Traumatic Stress Disorder, Springer, Cham, 1-13. https://doi.org/10.1007/978-3-319-08613-2_84-1
[8]
Soliman, F. (2010) Variant Brain-Derived Neurotrophic Factor Val66Met Endophenotypes: Implications for Posttraumatic Stress Disorder. Annals of the New York Academy of Sciences, 1208, 150-157.
https://doi.org/10.1111/j.1749-6632.2010.05722.x
[9]
Liu, Y., Garrett, M.E., Dennis, M.F., et al. (2015) An Examination of the Association between 5-HTTLPR, Combat Exposure, and PTSD Diagnosis among U.S. Veterans. PLoS ONE, 10, e0119998. https://doi.org/10.1371/journal.pone.0119998
[10]
Chen, T., Guo, M., Gao, Y.S., et al. (2014) A Comparative Study on the Levels of Serum Cytokines and Cortisol among Post-Traumatic Stress Disorder Patients of Li and Han Ethnicities in Hainan. National Medical Journal of China, 127, 2771-2774.
[11]
Kilpatrick, D.G. (2013) The DSM-5 Got PTSD Right: Comment on Friedman (2013). Journal of Traumatic Stress, 26, 563-566. https://doi.org/10.1002/jts.21844
[12]
Kilpatrick, D.G., Resnick, H.S., Milanak, M.E., et al. (2013) National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria. Journal of Traumatic Stress, 26, 537-547. https://doi.org/10.1002/jts.21848
[13]
Blake, D.D., et al. (1995) The Development of a Clinician-Administered PTSD Scale. Journal of Traumatic Stress, 8, 75-90. https://doi.org/10.1007/BF02105408
[14]
Buyati, D., Adila Duolikun, Y., Nanzamu, Y., et al. (2012) 5-HTTLPR Gene Insertion/Deletion Polymorphism Study and Longevity Association Analysis in Hetian Uygur Elderly. Science and Technology Review, 26, 59-63.
[15]
Xu, G.Z., Liu, Y., Zhang, Y., et al. (2015) Correlation between VEGFR2 rs2071559 Polymorphism and Glioma Risk among Chinese Population. International Journal of Clinical and Experimental Medicine, 8, 16724-16728.
[16]
Telch, M.J., Beevers, C.G., Rosenfield, D., et al. (2015) 5-HTTLPR Genotype Potentiates the Effects of War Zone Stressors on the Emergence of PTSD, Depressive and Anxiety Symptoms in Soldiers Deployed to Iraq. World Psychiatry, 14, 198-206.
https://doi.org/10.1002/wps.20215
[17]
Zhang, K., Xu, Q., Xu, Y., et al. (2009) The Combined Effects of the 5-HTTLPR and 5-HTR1A Genes Modulates the Relationship between Negative Life Events and Major Depressive Disorder in a Chinese Population. Journal of Affective Disorders, 114, 224-231. https://doi.org/10.1016/j.jad.2008.07.012
[18]
Su, Y.A., Jun, W., Lei, Z., et al. (2008) Dysregulated Mitochondrial Genes and Networks with Drug Targets in Postmortem Brain of Patients with Posttraumatic Stress Disorder (PTSD) Revealed by Human Mitochondria-Focused cDNA Microarrays. International Journal of Biological Sciences, 4, 223-235.
https://doi.org/10.7150/ijbs.4.223
[19]
Chen, Z.J., Zhao, H., He, L., et al. (2010) Genome-Wide Association Study Identifies Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics, 43, 55-59. https://doi.org/10.1038/ng.732
[20]
Neumeister, A. (2013) The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD. Journal of Depression & Anxiety, S4, 1-6.
https://doi.org/10.4172/2167-1044.S4-006
[21]
Young, K.A., Morissette, S.B., Jamroz, R., et al. (2017) 5-HTTLPR and DISC1 Risk Genotypes for Elevated PTSD Symptoms in US Military Veterans. World Psychiatry, 16, 109-110. https://doi.org/10.1002/wps.20359
[22]
Kanagaratnam, P. and Asbjornsen, A.E. (2007) Executive Deficits in Chronic PTSD Related to Political Violence. Journal of Anxiety Disorders, 21, 510-525.
https://doi.org/10.1016/j.janxdis.2006.06.008
[23]
Digangi, J.A., Kujawa, A., Aase, D.M., et al. (2017) Affective and Cognitive Correlates of PTSD: Electrocortical Processing of Threat and Perseverative Errors on the WCST in Combat-Related PTSD. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 75, 63-69. https://doi.org/10.1016/j.pnpbp.2017.01.004
[24]
Aupperle, R.L., Melrose, A.J., Stein, M.B. and Paulus, M.P. (2012) Executive Function and PTSD: Disengaging from Trauma. Neuropharmacology, 62, 686-694.
https://doi.org/10.1016/j.neuropharm.2011.02.008
[25]
Braithwaite, E.C., Ramchandani, P.G., O’Connor, T.G., et al. (2013) No Moderating Effect of 5-HTTLPR on Associations between Antenatal Anxiety and Infant Behavior. Journal of the American Academy of Child & Adolescent Psychiatry, 52, 519-526. https://doi.org/10.1016/j.jaac.2013.02.010
[26]
Plieger, T., Montag, C., Felten, A. and Reuter, M. (2014) The Serotonin Transporter Polymorphism (5-HTTLPR) and Personality: Response Style as a New Endophenotype for Anxiety. The International Journal of Neuropsychopharmacology, 17, 851-858. https://doi.org/10.1017/S1461145713001776
[27]
Hirohashi, S., Clausen, H., Nudelman, E.D., et al. (1986) A Human Monoclonal Antibody Directed to Blood Group I Antigen: Heterohybridoma between Human Lymphocytes from Regional Lymph Nodes of a Lung Cancer Patient and Mouse Myeloma. Journal of Immunology, 136, 4163-4168.
