Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior disorders, disorders of speech or language development, and learning disabilities. MNRI is based on techniques called “repatterning” or remodulation, meaning re-education, recoding the reflex nerve pathways specific for dynamic and postural reflex schemes. Objectives: Repatterning activates the extra pyramidal nervous system responsible for automatic mechanisms and processes, the extension of links between neurons, the growth of neural nets, myelination, and the creation of new nerve routing. This potential result was tested utilizing urinary measurements of the following neurotransmitters: epinephrine, norepinephrine, dopamine, DOPAC, serotonin, 5-HIAA, glycine, taurine, GABA, glutamate, PEA, and histamine. Methods: Neurological impact of the Masgutova Neurosensorimotor Reflex Method on the magnitude of changes in neurotransmitters was assessed by an external controlled and double-blind method using patients from one of the four diagnosis groups: 1) global developmental disorders; 2) cerebral palsy, Traumatic Brain Injury (TBI), Acute Brain Injury (ABI), and seizures; 3) ADD/ADHD; and 4) anxiety disorders. Results: The post-MNRI results in participants show a tendency for regulation of the above neurotransmitters resulting in their calming down, decrease of hypervigilance, stress resilience increase, improvements in behavioral and emotional regulation, positive emotions, and cognitive processes control. Conclusion: The application of the Masgutova Neurosensorimotor Reflex Method as a therapy modality offers a novelty paradigm for the treatment using neuro- and immune-modulation technologies presenting a non-pharmaceutical approach, based on use of neurosensorimotor reflex circuit concept.
References
[1]
Pitman, R.K., Shin, L.M. and Rauch, S.L. (2001) Investigating the Pathogenesis of Posttraumatic Stress Disorder with Neuroimaging. The Journal of Clinical Psychiatry, 62, 47-54.
[2]
Kollen, B., Lennon, S., Lyons, B., et al. (2009) The Effectiveness of the Bobath Concept in Stroke Rehabilitation. Stroke, 40, e89-e97.
https://doi.org/10.1161/STROKEAHA.108.533828
https://stroke.ahajournals.org/content/40/4/e89.full.pdf+html
[3]
Delacato, C.H. (1974) The Diagnosis and Treatment of Speech and Reading Problems. Doubleday, Garden City.
[4]
Vojta, V. (1989) Die Posturale Ontogenese als Basis der Entwicklungsstorungen. Monatsschr. Kinderheilkd.
[5]
Pilecki, W., Kipiński, L., Szawrowicz-Pełka, T., Kałka, D. and Masgutova, S. (2013) Spectral Brain Mapping in Children with Cerebral Palsy Treated by the Masgutova Neurosensorimotor Reflex Integration Method. Journal of the Neurological Sciences, 333, e550. https://doi.org/10.1016/j.jns.2013.07.1932
[6]
Pilecki, W., Masgutova, S., Kowalewska, J., Masgutov, D., Akhmatova, N., et al. (2012) The Impact of Rehabilitation Carried out Using the Masgutova Neurosensorimotor Reflex Integration Method in Children with Cerebral Palsy on the Results of Brain Stem Auditory Potential Examinations. Advances in Clinical and Experimental Medicine, 21, 363-371.
[7]
Koberda, J.L. and Akhmatova, N. (2016) Masgutova Neurosensorimotor Reflex Integration (MNRI) as a New Form of Manual Neuromodulation Technique. Journal of Neurology and Neurophysiology, 2.
https://doi.org/10.16966/2379-7150.e110
[8]
Koberda, J.L., Akhmatova, N., Akhmatova, E., Bienkiewicz, A., Nowak, K. and Nawrocka, H. (2016) Masgutova Neurosensorimotor Reflex Integration (MNRI) Neuromodulation Technique Induces Positive Brain Maps (QEEG) Changes. Journal of Neurology and Neurophysiology, 2. https://doi.org/10.16966/2379-7150.130
[9]
Masgutova, S., Akhmatova, N., Sadowska, L., Shackleford, P. and Akhmatov, E. (2016) Progress with Neurosensorimotor Reflex Integration for Children with Autism Spectrum Disorder. Journal of Neurology and Psychology, 4, 14.
https://doi.org/10.13188/2332-3469.1000028
[10]
Masgutova, S., Akhmatova, N. and Akhmatov, E. (2016) Neurosensorimotor Reflex Integration for Autism: A New Therapy Modality Paradigm. Journal of Pediatric Neurological Disorders, 2, 107.
[11]
Masgutova, S., Sadowska, L., Kowalewsk, J., Masgutov, J., Akhmatova, N. and Filipowski, H. (2015) Use of a Neurosensorimotor Reflex Integration Program to Improve Reflex Patterns of Children with Down Syndrome. Journal of Neurology and Neurosciences, 6, 59. https://doi.org/10.21767/2171-6625.100059
[12]
Masgutova, S., Akhmatova, N. and Sadowska, L. (2016) Reflex Profile of Children with Down Syndrome Improvement of Neurosensorimotor Development Using the MNRI Reflex Integration Program. International Journal of Neurorehabilitation, 3, 197. https://doi.org/10.4172/2376-0281.1000197
[13]
Akhmatova, N. and Akhmatova, E. (2016) Influence of MNRI on the Immune Status of Children with Down Syndrome. Journal of Clinical and Cellular Immunology, 8, 483. https://doi.org/10.4172/2155-9899.1000483
[14]
Akhmatova, N., Akhmatova, E. and Lebedinskaya, O. (2016) MNRI: An Immunomodulating Effect on Lymphocyte Subpopulation Structure of Children with Down Syndrome. Russian Journal of Immunology, 10, 485-487.
[15]
Akhmatova, E., Akhmatova, N. and Masgutova, S. (2016) MNRI: Immunocorrective Effect on the Immune Status of Children with Down Syndrome. 17th Biennial Meeting of the European Society for Immunodeficiencies, Barcelona, 21-24 September 2016.
[16]
Masgutova, S. (2016) Post-Trauma Recovery in Children of Newtown, CT Using MNRI Reflex Integration. Journal of Traumatic Stress Disorders & Treatment, 5, 5.
https://doi.org/10.4172/2324-8947.1000163
[17]
Masgutova, S. and Regner, A. (2008, 2011) Language Development Using Sensory-Motor Integration Approach. MISM, Wroclaw, 167 p.
[18]
Akhmatova, N., Masgutova, S., Sorokina, E., Akhmatov, E. and Lebedinskaya, O. (2015) Influence of Neuro-Sensory-Motor Reflex Integration Technique on Immune Response of Patients with Herpes-Associated Multiforme Erythema. 11th Congress of the Latin American Association of Immunology, October 2015, Medellin.
[19]
Masgutova, S., Akhmatova, S. and Kiselevsky, M. (2008) Immunologic Effects of Masgutova Neurosensorimotor Reflex Integration in Children with Recurrent Obstructive Bronchitis. Russian Journal of Immunology, 2, 454-463.
[20]
Renard-Fontaine, I.F. (2017) Effect of Reflex Neuromodulation on an Infant with Severe Amniotic Band Syndrome: A Case Report on the Use of Mnri Techniques for Physical Therapy. International Journal of Neurorehabilitation, 4, 248.
https://doi.org/10.4172/2376-0281.1000248
[21]
Nowak, K. and Sendrowski, K. (2016) Neurophysiological Aspects of Neurotactile Therapy of Masgutova Neurosensory Motor Reflex Integration MNRI Method. Rehabilitacja Medyczna, 21, 20-29.
[22]
Rentschler, M. and Averkamp, S. (2015) Reflexes: Portal to Neurodevelopment and Learning. A Collective Work. Svetlana Masgutova Educational Institute, Orlando.
[23]
Selye, H. (1974) Stress without Distress. J. B. Lippincott Co., Philadelphia.
[24]
Masgutova, S. (2016) PTSD Recovery: Gentle, Rapid, and Effective Treatment with Reflex Integration. SMEI, Orlando, 158 p.
[25]
Sechenov, I.M. (1965) Reflexes of the Brain (Russ. Tr. Belsky, S.). The MIT Press, Cambridge.
Pavlov, I.P. (1925/1960) Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex. Anrep, G.V., Trans., 1960. Dover Publications Inc., New York.
[28]
Anokhin, P.K. (1974) Biology and Neurophysiology of the Conditioned Reflex and Its Role in Adaptive Behavior. Pergamon Press, Oxford.
https://doi.org/10.1016/B978-0-08-021516-7.50009-4
[29]
Haines, D.E. (2002) Fundamental Neuroscience. 2nd Edition, The Curtis Center Independence Square West, Philadelphia.
[30]
Virella, G., Goust, J.M. and Fudenberg, H.H. (1990) Introduction to Medical Immunology. 2nd Edition, Marcel Dekker, New York.
[31]
Kagedal, B. and Goldstein, D.S. (1988) Catecholamines and Their Metabolites. Journal of Chromatography, 429, 177-233.
https://doi.org/10.1016/S0378-4347(00)83871-2
[32]
Westermann, B. (2002) Merging Mitochondria Matters: Cellular Role and Molecular Machinery of Mitochondrial Fusion. EMBO Reports, 3, 527-531.
https://doi.org/10.1093/embo-reports/kvf113
[33]
Panholzer, T.J., Beyer, J. and Lichtwald, K. (1999) Coupled-Column Liquid Chromatographic Analysis of Catecholamines, Serotonin, and Metabolites in Human Urine. Clinical Chemistry, 45, 262-268.
[34]
Bloom, F.E. and Kupfer, D.J. (1995) Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York.
[35]
Lynn-Bullock, C.P., Welshhans, K., Pallas, S.L. and Katz, P.S. (2004) The Effect of Oral 5-HTP Administration on 5-HTP and 5-HT Immunoreactivity in Monoaminergic Brain Regions of Rats. Journal of Chemical Neuroanatomy, 27, 129-138.
https://doi.org/10.1016/j.jchemneu.2004.02.003
[36]
Marc, D.T., Ailts, J.W., Campeau, D.C., Bull, M.J. and Olson, K.L. (2010) Neurotransmitters Excreted in the Urine as Biomarkers of Nervous System Activity: Validity and Clinical Applicability. Neuroscience & Biobehavioral Reviews, 35, 635-644. https://doi.org/10.1016/j.neubiorev.2010.07.007
[37]
Borodinsky, L.N., Belgacem, Y.H., Swapna, I. and Sequerra, E.B. (2005/2012) Dynamic Regulation of Neurotransmitter Specification: Relevance to Nervous System Homeostasis. Neuropharmacology, 78, 75-80.
https://doi.org/10.1016/j.neuropharm.2012.12.005
[38]
MarcJoseph, D.T., Ailts, J.W., Ailts Campeau, D.C., Bull, M.J. and Olson, K.L. (2011) Neurotransmitters Excreted in the Urine as Biomarkers of Nervous System Activity: Validity and Clinical Applicability. Neuroscience & Biobehavioral Reviews, 35, 635-644. https://doi.org/10.1016/j.neubiorev.2010.07.007
[39]
Ziemssen, T. and Kern, S. (2007) Psychoneuroimmunology Cross-Talk between the Immune and Nervous Systems. Journal of Neurology, 254, II8-II11.
https://doi.org/10.1007/s00415-007-2003-8
[40]
Spitzer, N.C. (2010) How GABA Generates Depolarization. The Journal of Physiology, 588, 757-758. https://doi.org/10.1113/jphysiol.2009.183574
[41]
Kriegsfeld, L.J. and Silver, R. (2006) The Regulation of Neuroendocrine Function: Timing Is Everything. Hormones and Behavior, 49, 557-574.
https://doi.org/10.1016/j.yhbeh.2005.12.011
[42]
Levinson, A.J. and Zafiris, J. (2010).
https://www.eurekalert.org/pub_releases/2010-03/cfaa-cbc030110.php
[43]
Yang, E.V. and Glaser, R. (2000) Stress-Induced Immunomodulation: Impact on Immune Defenses against Infectious Disease. Biomedicine & Pharmacotherapy, 54, 245-250. https://doi.org/10.1016/S0753-3322(00)80066-9
[44]
Cooper, A. and Jeitner, T. (2016) Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain. Biomolecules, 6, 16. https://doi.org/10.3390/biom6020016
[45]
Zecca, L., et al. (2003) The Neuromelanin of Human Substantia Nigra: Structure, Synthesis and Molecular Behaviour. In: Horowski, R., et al., Eds., Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementa, 65, 145-155. https://doi.org/10.1007/978-3-7091-0643-3_8
[46]
Daw, N.D., Kakade, S. and Dayan, P. (2002) Opponent Interactions between Serotonin and Dopamine. Neural Networks, 15, 603-616.
https://doi.org/10.1016/S0893-6080(02)00052-7
[47]
Davidson, R.J., Putnam, K.M. and Larson, C.L. (2000) Dysfunction in the Neural Circuitry of Emotion Regulation—A Possible Prelude to Violence. Science, 289, 591-594. https://doi.org/10.1126/science.289.5479.591
[48]
Gatley, S.J., Volkow, N.D., Gifford, A.N., Fowler, J.S., Dewey, S.L., Ding, Y.S. and Logan, J. (1999) Dopamine-Transporter Occupancy after Intravenous Doses of Cocaine and Methylphenidate in Mice and Humans. Psychopharmacology, 146, 93-100. https://doi.org/10.1007/s002130051093
[49]
Prentice, H., Gharibani, P.M., Ma, Z., Alexandrescu, A., Genova, R., Chen, P.C., Modi, J., Pan, C., Tao, R. and Wu, J.Y. (2017) Neuroprotective Functions through Inhibition of ER Stress by Taurine or Taurine Combination Treatments in a Rat Stroke Model. Advances in Experimental Medicine and Biology Taurine, 10, 193-205. https://doi.org/10.1007/978-94-024-1079-2_17
[50]
Jia, F., Yue, M., Chandra, D., Keramidas, A., Goldstein, P.A., Homanics, G.E. and Harrison, N.L. (2008) Taurine Is a Potent Activator of Extrasynaptic GABAA Receptors in the Thalamus. Journal of Neuroscience, 28, 106-115.
https://doi.org/10.1523/JNEUROSCI.3996-07.2008
[51]
Wu, J.-Y. and Prentice, H. (2010) Role of Taurine in the Central Nervous System. Journal of Biomedical Science, 17, S1. https://doi.org/10.1186/1423-0127-17-S1-S1
[52]
Brozoski, T.J., Caspary, D.M., Bauer, C.A. and Richardson, B.D. (2010) The Effect of Supplemental Dietary Taurine on Tinnitus and Auditory Discrimination in an Animal Model. Hearing Research, 270, 71-80.
https://doi.org/10.1016/j.heares.2010.09.006
[53]
Wada, H., Inagaki, N., Yamatodani, A. and Watanabe, T. (1991) Is the Histaminergic Neuron System a Regulatory Center for Whole-Brain Activity? Trends in Neurosciences, 14, 415-418. https://doi.org/10.1016/0166-2236(91)90034-R
[54]
Kjaer, A., Knigge, U., Rouleau, A., Garbarg, M. and Warberg, J. (1994) Dehydration-Induced Release of Vasopressin Involves Activation of Hypothalamic Histaminergic Neurons. Endocrinology, 135, 675-681.
https://doi.org/10.1210/endo.135.2.8033816
[55]
Knigge, U. and Warberg, J. (1991) The Role of Histamine in the Neuroendocrine Regulation of Pituitary Hormone Secretion. Acta Endocrinologica (Copenhagen), 124, 609-619. https://doi.org/10.1530/acta.0.1240609
[56]
Zhong, Z., Wheeler, M.D., Li, X., Froh, M., Schemmer, P., Yin, M., Bunzendaul, H., Bradford, B. and Lemasters, J.J. (2003) L-Glycine: A Novel Antiinflammatory, Immunomodulatory, and Cytoprotective Agent. Current Opinion in Clinical Nutrition & Metabolic Care, 6, 229-240. https://doi.org/10.1097/00075197-200303000-00013
[57]
Baker, G.B., Bornstein, R.A., Rouget, A.C., Ashton, S.E., van Muyden, J.C. and Coutts, R.T. (1991) Phenylethylaminergic Mechanisms in Attention-Deficit Disorder. Biological Psychiatry, 29, 15-22.
https://doi.org/10.1016/0006-3223(91)90207-3
[58]
Butler, P.D., Susser, E.S., Brown, A.S., Kaufman, C.A. and Gorman, J.M. (2003) Prenatal Nutritional Deprivation as a Risk Factor in Schizophrenia: Preclinical Evidence. Neuropsychopharmacology, 11, 227-235.
[59]
Irsfeld, M., Spadafore, M. and Prüß, B.M. (2013) β-Phenylethylamine, a Small Molecule with a Large Impact. WebmedCentral, 4, 4409.
[60]
Ortego, L., Pelican, E., Callaba, L. and Marks, T. (2015) An Investigation of the Effects of MNRI Techniques on the Educational Performance of Kindergarten Students. In: Reflexes: Portal to Neurodevelopment and Learning, a Collective Work, SMEI, Orlando, 142-156.
[61]
Akhmatova, N., Masgutova, S., Shubina, I., Akhmatov, E., Khomenkov, V., Sorokina, E., Korovkina, E. and Kostinov, M. (2015) Immunological Effects of Masgutova Neurosensorimotor Reflex Integration in Children with Recurrent Obstructive Bronchitis. International Journal of Neurorehabilitation, 2, 166-175.
[62]
Delahanty, D.L., Nugent, N.R., Christopher, N.C. and Walsh, M. (2005) Initial Urinary Epinephrine and Cortisol Levels Predict Acute PTSD Symptoms in Child Trauma Victims. Psychoneuroendocrinology, 30, 121-128.
https://doi.org/10.1016/j.psyneuen.2004.06.004
[63]
Kim, K.S., Oh, D., Kim, J.Y., et al. (2012) Taurine Ameliorates Hyperglycemia and Dyslipidemia by Reducing Insulin Resistance and Leptin Level in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with Long-Term Diabetes. Experimental & Molecular Medicine, 44, 665-673.
https://doi.org/10.3858/emm.2012.44.11.075
Wilcox, K.S., Buchhalter, J. and Dichter, M.A. (1994) Properties of Inhibitory and Excitatory Synapses between Hippocampal Neurons in Very Low Density Cultures. Synapse, 18, 128-151. https://doi.org/10.1002/syn.890180206
[66]
Fletcher, E.V., Simon, C.M., Pagiazitis, J.G., Chalif, J.I., Vukojicic, A., et al. (2017) Reduced Sensory Synaptic Excitation Impairs Motor Neuron Function via Kv2.1 in Spinal Muscular Atrophy. Nature Neuroscience, 20, 905-916.
https://doi.org/10.1038/nn.4561
[67]
https://opentextbc.ca/anatomyandphysiology
[68]
Miller, A.H., Haroon, E., Raison, C.L. and Felger, J.C. (2013) Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits. Depress Anxiety, 30, 297-306. https://doi.org/10.1002/da.22084
[69]
Harris, K.D., Weiss, M. and Zahavi, A. (2014) Why Are Neurotransmitters Neurotoxic? An Evolutionary Perspective. F1000Research, 3, 179.
https://doi.org/10.12688/f1000research.4828.2
[70]
Young, S.N. and Leyton, M. (2002) The Role of Serotonin in Human Mood and Social Interaction. Insight from Altered Tryptophan Levels. Pharmacology Biochemistry and Behavior, 71, 857-865. https://doi.org/10.1016/S0091-3057(01)00670-0
[71]
Institute of Medicine (US) Forum on Neuroscience and Nervous System Disorders (2011) Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary. National Academies Press, Washington DC.
https://www.ncbi.nlm.nih.gov/books/NBK62187
Drevets, W.C., Price, J.L. and Furey, M.L. (2008) Brain Structural and Functional Abnormalities in Mood Disorders: Implications for Neurocircuitry Models of Depression. Brain Structure & Function, 213, 93-118.
https://doi.org/10.1007/s00429-008-0189-x
[74]
Schaumann, T., Kraus, D., Winter, J., Wolf, M., Deschner, J. and Jäger, A. (2013) Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation. Clinical & Developmental Immunology, 2013, Article ID: 808367.
https://doi.org/10.1155/2013/808367
[75]
Akhmatova, N., Masgutova, S., Lebedinskaya, O., Akhmatov, E. and Shubina, I. (2015) Immunological Efficiency of MNRI Program at Treatment of Respiratory Diseases. 11th Congress of the Latin American Association of Immunology, Medellin, 13-16 October 2015. https://doi.org/10.3389/conf.fimmu.2015.05.00072
[76]
Tank, A.W. and Wong, D.L. (2015) Peripheral and Central Effects of Circulating Catecholamines. Comprehensive Physiology, 5, 1-15.
https://doi.org/10.1002/cphy.c140007
[77]
Hough, L.B. (1999) Histamine Actions in the Central Nervous System. In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th Edition, Lippincott-Raven, Philadelphia. http://ncbi.nlm.nih.gov/books/NBK28245
[78]
Haas, H.L., Sergeeva, O.A. and Selbach, O. (2008/2012) Histamine in the Nervous System. Physiological Reviews, 88, 1183-1241.
https://doi.org/10.1152/physrev.00043.2007
[79]
Strac, D.S., Pivac, N., Smolders, I.J., Fogel, W.A., Deurwaerdere, P.D. and Giovanni, G.D. (2016) Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs. Frontiers in Neuroscience, 10, 492. https://doi.org/10.3389/fnins.2016.00492
[80]
Schaffer, S. and Kim, H.W. (2018) Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomolecules & Therapeutics (Seoul), 26, 225-241.
https://doi.org/10.4062/biomolther.2017.251
[81]
Oja, S.S. and Saransaari, P. (2017) Significance of Taurine in the Brain. Advances in Experimental Medicine and Biology, 975, 89-94.
https://doi.org/10.1007/978-94-024-1079-2_8
[82]
Alaniz-Palacios, A. and Martínez-Torres, A. (2017) Antagonistic Effect of Dopamine Structural Analogues on Human GABAρ1 Receptor. Scientific Reports, 7, Article No. 17385. http://www.nature.com/articles/s41598-017-17530-8
https://doi.org/10.1038/s41598-017-17530-8
[83]
Kusaga, A. (2002) Decreased Beta-Phenylethylamine in Urine of Children with Attention Deficit Hyperactivity Disorder and Autistic Disorder. Brain and Development, 34, 243-248.
[84]
Sarkar, A., Lehto, S.M., Harty, S., Dinan, T.G., Cryan, J.F. and Burnet, P. (2016) Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends in Neurosciences, 39, 763-781. https://doi.org/10.1016/j.tins.2016.09.002
