|
|
- 2016
乌司他丁对缺血性脑血管病介入治疗患者血清S100B质量浓度及术后认知功能的影响
|
Abstract:
摘要 目的: 研究乌司他丁对缺血性脑血管病介入治疗患者血清S100B质量浓度及认知功能的影响,探讨乌司他丁对脑缺血患者的脑保护作用.方法: 本研究为随机对照临床研究,选择拟在全麻下行介入治疗的缺血性脑血管病患者60例,性别不限,年龄40~65岁,BMI 20~30 kg/m2,将其随机分为两组(n=30):乌司他丁组(U组)和对照组(C组).U组患者麻醉诱导前30 min给予乌司他丁10 000 U/kg(由生理盐水稀释至100 mL静脉滴注),C组患者在相同时间段静脉滴注100 mL生理盐水.于手术前及术后第1、3天行外周静脉采血,采用ELISA检测患者血清S100B质量浓度;同时在两组患者手术前及术后第1、3天,用MMSE评价其认知功能. 结果: 术后第1天和第3天,U组患者血清S100B质量浓度显著低于C组(P<0.05);同时,术后第1天,U组患者MMSE评分高于C组(P<0.05).结论: 乌司他丁预处理可降低缺血性脑血管病介入治疗患者血清S100B质量浓度并改善患者术后早期认知功能,具有一定的脑保护作用.
| [1] | 王盼,张熙,周波,等.蒙特利尔认知评价量表(中文版)在轻度认知损害诊断及进展过程中的作用[J].中国现代神经疾病杂志,2012,12(2):193-197. |
| [2] | DELGADO P, ALVAREZ SABIN J, SANTMARINA E A, et al. Plasma S100B level after acute spontaneous intracerebral hemorrhage[J]. Stroke, 2006,37(11): 2837-2839. |
| [3] | STEINER J, BEINSTEIN H G, BIELAU H, et al. Evidence for a wide extra-astrocytic distribution of S100B in human brajn[J]. BMC Neurosci, 2007, 8(2):1-10. |
| [4] | ZHAI J, CHENG L, DONG J, et al. S100B gene polymorphisms predict prefontal spatial function in both schizophrenia patients and healthy individual[J]. Schizophr Res, 2012,134(1):89-94. |
| [5] | BAYRAM H, HIDIROGLU M, CETIN L, et al. Comparring S100 beta protein levels and neurocognitive functions between patients undergoing on-pump and off-pump coronary artery bypass grafting[J]. J Surg Res, 2013,182(2):198-202. |
| [6] | 赵姜,吴岩.脂联素与缺血性脑血管病研究进展[J].天津医药.2013,41(12):1226-1228. |
| [7] | 李立,吴世政,张淑坤.小胶质细胞在缺血性脑卒中的神经保护作用[J].实用医学杂志.2014,30(23):3860-3862. |
| [8] | THELIN E P, JOHANNESSON L, NELSON D, et al. S100B is an important outcome predictor in traumatic brain injury[J]. J Neurotrauma, 2013,30(7):519-528. |
| [9] | SUI B, LI Y W, MA L. Postconditioning improvement effects of ulinastatin on brain injury following cardiopulmonary resuscitation[J]. Experimental And Therapeutic Medicine,2014,8(4):1301-1307. |
| [10] | DERECKI N C, CARDANI A N, YANG C H,et al. Regulation of learning and memory by meningeal immunity: a key role for IL-4[J]. J Exp Med, 2010,207(5):1067-1080. |
| [11] | MASSARO AN, CHANG T, KADOM N, et al. Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia[J]. J Pediatr, 2012,161(3):434-440. |
| [12] | SANDLER S J, FIGAJI A A, ADELSON P D. Clinical applications of biomarkers in pediatric traumatic brain injury[J]. Childs Nerv Syst, 2010,26(2):205-213. |
| [13] | MONK T G, WELDON B C, GARVAN C W, et al. Predictors of cognitive dysfunction after major noncardiac surgery[J]. Anesthesiology, 2008,108(1):18. |
| [14] | INGRID R. Postoperative cognitive dysfunction[J]. Dtsch Arztebl Int, 2014, 111(8):119-125. |
| [15] | 马春野,刘彬,尹琳.CD8T淋巴细胞在大鼠缺血再灌注脑组织中表达的变化[J].中华老年心脑血管杂志,2013,15(10):1077-1080. |
| [16] | DHAWAN J, BENVENISTE H, NAWROCKY M, et al. Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptors[J]. Neuroimage, 2010, 51(2):599-605. |
| [17] | 李雅薇,王东信.炎性反应与术后认知功能并发症的关系研究进展[J].解放军医学杂志,2014,39(8):673-677. |
| [18] | AOSASA S, ONO S, MOCHIZUKI H, et al. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes[J]. Shock, 2001,15(2):101-105. |
