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- 2018
钆塞酸二钠增强MRI与Child-Pugh分级及血清指标评价肝功能的对照研究
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Abstract:
摘要 目的: 探讨钆塞酸二钠(Gd-EOB-DTPA) 增强核磁共振扫描(MRI)对肝实质相对强化程度(RE)的评估并将肝功能分级与血清指标进行对照研究. 方法: 收集Gd-EOB-DTPA MRI增强扫描病例资料共64例,按对照组与不同Child-Pugh等级分组,采用one-way ANOVA比较各组间RE值的差异,绘制受试者工作特征曲线(ROC)曲线分析RE值评估肝功能的效能,并观察Pearson相关系数检验RE值与各血清生化指标的相关性. 结果: 延迟期、肝胆细胞期组间RE值存在统计学差异(P<0.05).ROC曲线显示对照组VS Child-Pugh A组+Child-Pugh B组+Child-Pugh C组延迟期、肝胆细胞期RE值曲线下面积(AUC)分别为0.676、0.702,对照组+Child-Pugh A组VS Child-Pugh B组+Child-Pugh C组延迟期、肝胆细胞期RE值AUC分别为0.719、0.819,对照组+Child-Pugh A组+Child-Pugh B组VS Child-Pugh C组延迟期、肝胆细胞期RE值AUC分别为0.750、0.859.肝胆细胞期RE值与ALB、GLB、TBIL、DBIL、TBA具有相关性(P<0.05). 结论: Gd-EOB-DTP MRI增强扫描肝胆细胞期RE值能评价肝脏受损的程度,具有较高的诊断效能,对评估肝功能具有一定临床意义.
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