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- 2017
咳嗽变异性哮喘与典型支气管哮喘患者外周血树突状细胞的变化
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Abstract:
摘要 目的计算咳嗽变异性哮喘(CVA)、典型支气管哮喘(CA)患者,其外周血中树突状细胞(DCs)及亚型髓样树突状细胞(mDC)、浆细胞样树突状细胞(pDC)比例和数量的变化,了解咳嗽变异性哮喘与典型支气管哮喘之间是否有类似的免疫学发病机制.方法:选取CA患者20例,CVA患者17例,对照组健康人17例,使用流式细胞术检测和计算CA组与CVA组受试者外周血中DCs及其两个亚群:pDC和mDC所占比例和数量的变化.结果:咳嗽变异性哮喘与典型支气管哮喘患者相比,其外周血树突状细胞及其亚型的数量和比例均无明显差异, 咳嗽变异性哮喘、典型支气管哮喘患者较健康对照组,pDC数量及比例的增高明显,mDCs/pDCs的比值降低有统计学差异.结论:咳嗽变异性哮喘与支气管哮喘的发病机制在免疫学上类似,由于pDCs比例和数量的增多引起Th2细胞数量增多,造成Th1/Th2平衡向Th2细胞偏移.
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