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- 2017
抑郁症患者血清微量元素、铜蓝蛋白与执行功能的关系
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Abstract:
摘要 目的: 探讨抑郁症患者(MDD)血清微量元素、铜蓝蛋白(Cp)与执行功能的关系.方法: 采用威斯康星卡片分类测验(WCST)及连线测验(TMT)评估35例符合美国精神障碍统计与诊断手册第5版(DSM-5)诊断标准的抑郁症患者和 30例正常对照者的执行功能,检测两组的血清铜(Cu)、锌(Zn)和Cp含量并探讨这3种物质与执行功能的相关性.结果: 抑郁组患者在TMT(反应时)和WCST测验(分类数、总错误数、持续错误数和非持续错误数)的成绩均低于对照组,差异具有统计学意义(P<0.05);抑郁组患者血清Zn、Cp水平明显低于对照组,Cu离子含量显著高于正常对照组,差异具有统计学意义(P<0.05);抑郁组患者血清中的Cp含量与TMT(反应时、错误数)的成绩呈正相关,与WCST非持续性错误数呈负相关;抑郁组Cu含量与TMT(提笔数)呈正相关.结论: 抑郁症患者的执行功能可能与铜和铜蓝蛋白密切相关.
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