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- 2018
中空纤维更新液膜萃取回收青霉素G
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Abstract:
采用中空纤维更新液膜对青霉素G溶液进行萃取回收．以安伯莱特离子交换树脂(Amberlite LA-2)、正辛醇、煤油作为液膜相, Na2CO3溶液作为反萃相, 研究了载体浓度、油水比、进料相青霉素G浓度、进料相pH、反萃相pH、两相流率对萃取率的影响, 确定了最适操作条件．结果表明：载体Amberlite LA-2浓度为100 mmol/L、油水比为1∶20、进料相青霉素G浓度为10 mmol/L、进料相pH为5、反萃相pH为10、管程流速为0.6 cm/s、壳程流速为0.48 cm/s时, 青霉素G的萃取率能达到85% , 展现出很好的工业应用前景．
The hollow fiber renewal liquid membrane was used for the extraction and recovery of penicillin G solution. The organic solution of Amberlite LA-2，1-octanol and kerosene was used as liquid membrane phase and Na2CO3 solution was used as stripping phase. The effects of carrier concentration，ratio of oil to water，penicillin G concentration in the feed phase，pH of the feed phase，pH of the stripping phase，and flow rates of two phases on the extraction efficiency were studied，and the optimum operation conditions were determined. The results demonstrate that the extraction efficiency could reach 85% when the carrier(Amberlite LA-2)concentration is 100 mmol/L，ratio of oil to water is 1∶20，penicillin G concentration in the feed phase is 10 mmol/L，pH of the feed phase is 5，pH of the stripping phase is 10，the tube side flow rate is 0.6 cm/s，and the shell side flow rate is 0.48 cm/s，which shows a good industrial application prospect
| [1] | Shen Liren, Yang Pinzhao, Ji Weiqing, et al. Extraction of the penicillin G from simulated fermentation solution by an emulsion liquid membrane process[J]. <i>Membrane Science and technology</i>, 1997, 17(1):24-28(in Chinese). |
| [2] | Ren Z, Lü Y, Zhang W. Facilitated transport of penicillin G by bulk liquid membrane with TBP as carrier[J]. <i>Applied Biochemistry & Biotechnology</i>, 2009, 152(2):286-294. |
| [3] | 张卫东, 李爱民, 李雪梅, 等. 液膜技术原理及中空纤维更新液膜[J]. 现代化工, 2005, 25(4):66-68. |
| [4] | Ren Z, Zhang W, Li H, et al. Mass transfer characteristics of citric acid extraction by hollow fiber renewal liquid membrane[J]. <i>Chemical Engineering Journal</i>, 2009, 146(2):220-226. |
| [5] | 李皓淑, 任钟旗, 张卫东, 等. 利用中空纤维更新液膜技术从稀溶液中提取柠檬酸[J]. 食品科技, 2007, 33(10):141-144. |
| [6] | Ren Z, Zhang W, Meng H, et al. Extraction separation of Cu(Ⅱ)and Co(Ⅱ)from sulfuric solutions by hollow fiber renewal liquid membrane[J]. <i>Journal of Membrane Science</i>, 2010, 365(1/2):260-268. |
| [7] | 高磊, 韩俭, 刘君腾, 等. TBP-异辛醇-煤油体系中空纤维更新液膜萃取青霉素G[J]. 中国科技论文, 2010, 5(9):726-730. |
| [8] | Smith E, Hossain M M. Extraction and recovery of penicillin G in a hollow-fiber membrane contactor[J]. <i>Asia-Pacific Journal of Chemical Engineering</i>, 2010, 2(5):455-459. |
| [9] | Gao Lei, Han Jian, Liu Junteng, et al. Extraction of penicillin G with TBP-iso-octanol-kerosene in hollow fiber renewal liquid membrane[J]. <i>China Science Paper</i>, 2010, 5(9):726-730(in Chinese). |
| [10] | Ren Z, Zhang W, Lü Y, et al. Simultaneous extraction and concentration of penicillin G by hollow fiber renewal liquid membrane[J]. <i>Biotechnology Progress</i>, 2009, 25(2):468-475. |
| [11] | He L, Li L, Sun W, et al. Extraction and recovery of penicillin G from solution by cascade process of hollow fiber renewal liquid membrane[J]. <i>Biochemical Engineering Journal</i>, 2016, 110(11):8-16. |
| [12] | Hossain M M, Dean J. Extraction of penicillin G from aqueous solutions:Analysis of reaction equilibrium and mass transfer[J]. <i>Separation & Purification Technology</i>, 2008, 62(2):437-443. |
| [13] | Cascaval D, Oniscu C, Cascaval C. Selective separation of penicillin V from phenoxyacetic acid using liquid membranes[J]. <i>Biochemical Engineering Journal</i>, 2000, 5(1):45-50. |
| [14] | Kocherginsky N M, Yang Q, Seelam L. Recent advances in supported liquid membrane technology[J]<i>. Separation & Purification Technology</i>, 2007, 53(2):171-177. |
| [15] | Yang X J, Fane A G, Soldenhoff K. Comparison of liquid membrane processes for metal separations:Permeability, stability, and selectivity[J]<i>. Ind Eng Chem Res</i>, 2003, 42(2):392-403. |
| [16] | Zhang Weidong, Li Aiming, Li Xuemei, et al. Principle of liquid membrane and hollow fiber renewal liquid membrane[J]. <i>Modern Chemical Industry</i>, 2005, 25(4):66-68(in Chinese). |
| [17] | Ren Z, Yang Y, Zhang W, et al. Modeling study on the mass transfer of hollow fiber renewal liquid membrane:Effect of the hollow fiber module scale[J]. <i>Journal of Membrane Science</i>, 2013, 439(14):28-35. |
| [18] | Li Haoshu, Ren Zhongqi, Zhang Weidong, et al. Extraction of citric acid from dilute solutions with hollow fiber renewal liquid membrane technology[J]. <i>Food Science & Technology</i>, 2007, 33(10):141-144(in Chinese). |
| [19] | Ren Z, Zhang W, Liu Y M, et al. New liquid membrane technology for simultaneous extraction and stripping of copper(Ⅱ)from wastewater[J]. <i>Chemical Engineering Science</i>, 2007, 62(22):6090-6101. |
| [20] | Liu J, Zhang W, Ren Z, et al. The separation and concentration of Cr(Ⅵ)from acidic dilute solution using hollow fiber renewal liquid membrane[J]. <i>Industrial & Engineering Chemistry Research</i>, 2009, 48(9):4500-4506. |
| [21] | Ren Z, Zhang W, Dai Y, et al. Modeling of effect of pH on mass transfer of Copper(Ⅱ)extraction by hollow fiber renewal liquid membrane[J]. <i>Industrial & Engineering Chemistry Research</i>, 2008, 47(12):4256-4262. |
| [22] | Fortuny A, Coll M T, Sastre A M. Ionic liquids as a |
| [23] | Ren Z, Zhu X Y, Liu W, et al. Removal of aniline from wastewater using hollow fiber renewal liquid membrane[J]. <i>Chinese Journal of Chemical Engineering</i>, 2014, 22(11/12):1187-1192. |
| [24] | Sang C L. Kinetics of reactive extraction of penicillin G by amberlite LA-2 in kerosene[J]. <i>AIChE Journal</i>, 2010, 50(1):119-126. |
| [25] | Juang R S, Lee S H, Shiau R C. Carrier-facilitated liquid membrane extraction of penicillin G from aqueous streams[J]. <i>Journal of Membrane Science</i>, 1998, 146(1):95-104. |
| [26] | 沈力人, 杨品钊, 吉炜青, 等. 液膜法萃取青霉素的研究[J]. 膜科学与技术, 1997, 17(1):24-28. |
| [27] | carrier for chloride reduction from brackish water using hollow fiber renewal liquid membrane[J]. <i>Desalination</i>, 2014, 343(12):54-59. |
