留存肾功能正常者99mTc-DTPA显像参数正常值的建立
Normal reference of 99mTc-DTPA renal dynamic imaging parameters of compensatory residual kidney

目的:建立一侧肾无功能或缺失、对侧肾功能代偿患者99mTc-DTPA肾动态显像肾小球滤过率(GFR)、高峰时间(tb)及半排时间(C1/2)正常参考值范围。方法:回顾分析115例单侧肾功能正常而对侧肾缺如或无功能检查者的99mTc-DTPA肾动态显像结果,统计其GFR、显像剂摄取tb及C1/2。同时收集102例健康供肾者作为正常对照。结果:115例留存肾99mTc-DTPA肾动态显像的GFR、tb、C1/2正常参考值范围分别为(37.19～102.58)mL/min、(2.10～4.23)min、(6.50～21.51)min。无论留存肾是左肾还是右肾,两者的GFR、tb及C1/2比较差异均无统计学意义(P>0.05)。留存肾GFR较供体肾代偿性增加(t=9.363,P<0.001)。留存肾tb较供体肾延长(Z=3.595,P<0.001)。青年组、中年组和老年组组间GFR比较差异有统计学意义(F=6.130,P=0.003),青年组和中年组留存肾较供体肾GFR分别增加了47%和37%。结论:建立留存肾功能正常检查者99mTc-DTPA显像 GFR、tb、C1/2等参数的正常值参考范围,能够客观、有效地评价肾小球滤过功能,为临床诊疗提供依据。
Aim: To establish the normal reference range of compensatory residual kidney function parameters using 99mTc-DTPA renal dynamic imaging.Methods: A total of 115 patients with normal unilateral renal function and the contralateral kidney non-function or received nephrectomy, and 102 donors(control group)were collected. Parameters including glomerular filtration rate(GFR), the peak time of nephrogram(tb)and half time of kidney washout(C1/2)were collected.Results: The normal reference range of GFR,tb, and C1/2 in 115 cases of renal 99mTc-DTPA renal dynamic imaging were(37.19-102.58)mL/min,(2.10-4.23)min,(6.50-21.51)min, respectively. There was no significant difference in GFR,tb, and C1/2 between the residual left and the residual right kidneys(P>0.05). GFR of the residual kidneys was statistically higher than that of donor kidneys(t=9.363,P<0.001). The tb of the residual kidneys was statistically longer than that of normal donor kidneys(Z=3.595,P<0.001). Compared with control group, GFR of the young group and the middle-aged group increased by 47% and 37%(F=6.130,P=0.003), respectively.Conclusion: The established normal reference range of GFR, tb, C1/2 based on 99mTc-DTPA imaging could be impersonality and efficiency to evaluate glomerular filtration function,and provide a basis for clinical diagnosis and treatment