原发睾丸淋巴瘤的临床特点及预后影响因素分析*
Clinical characteristics and prognosis influnencing factors of primary testicular lymphoma

目的:探讨原发睾丸淋巴瘤(PTL)患者的临床特点和预后影响因素。方法:回顾性分析28例PTL患者的临床资料,以Kaplan-Meier法绘制生存曲线,Log-rank检验进行PTL患者预后的单因素分析,采用COX回归模型评估预后独立的影响因素。结果:经4～7周期化疗和(或)放疗后,其中死亡8例,完全缓解9例(32.1%),部分缓解8例(28.6%),疾病进展3例(10.7%)。客观缓解率为60.7%(17/28)。无疾病进展期12.4个月,总生存期35.1个月,中位随访时间35(6～90)个月。COX回归分析结果显示结外受侵个数、病理类型和B症状是PTL预后的独立影响因素[β=2.122,2.269,1.971; HR=8.346,9.668,7.175; 95%CI=1.159～60.088,1.526～61.230,1.170～44.007]。结论:结外受侵个数、病理类型和B症状是影响PTL患者预后的重要因素。
Aim: To investigate the clinical characteristics and factors affecting prognosis of patients with primary testicular lymphoma(PTL).Methods: A retrospective analysis of 28 cases with PTL admitted in the First Affiliated Hospital of Zhengzhou University from September, 2001 to July, 2014 were carried out. Survival curve was estimated using Kaplan-Meier method. Univariate analysis of prognosis in patients with PTL was performed by the Log-rank test. Multivariate analysis using COX regression models was performed to assess independent prognostic factors.Results: After treatment of 4-7 cycles chemotherapy and(or)radiotherapy, 8 patients were dead, 9 patients achieved complete remission(32.1%), 8 patients achieved partial remission(28.6%), 3 patients resulted in progression of disease(10.7%). The objective remission rate was 60.7%(17/28). The progression-free survival was 12.4 months. The overall survival was 35.1 months. The median follow-up time was 35(6-90)months. COX regression analysis indicated that the number of extranodal invasion, the type of pathology and B symptoms were independent prognostic factors of PTL(β=2.122,2.269,1.971; HR=8.346,9.668,7.175; 95%CI=1.159-60.088,1.526-61.230,1.170-44.007).Conclusion: The number of extranodal invasion, pathological types and B symptoms are important prognostic factors for prognosis of PTL