肺腺癌组织中FAM83A的表达
Expression of FAM83A in lung adenocarcinoma tissue

目的:探讨FAM83A在肺腺癌组织中的表达及临床意义。方法:从癌症基因组图谱(TCGA)数据库中下载癌旁正常及肺腺癌组织中FAM83A mRNA表达的数据及其相关的临床资料。根据FAM83A mRNA表达量将肺腺癌患者分为FAM83A mRNA低表达组与高表达组,分析FAM83A mRNA的表达与患者临床病理特征的关系。结果:肺腺癌组FAM83A mRNA的表达高于癌旁正常对照组(P=0.001)。FAM83A mRNA的表达量与肺腺癌患者的临床分期、TNM分期中的T分期和N分期有关(P均<0.05)。FAM83A mRNA低表达组的中位生存时间为1 622 d,高于高表达组(1 357 d)(P=0.001)。结论:肺腺癌组织中FAM83A mRNA的表达升高; FAM83A mRNA高表达及临床分期较晚与肺腺癌预后不良有关。
Aim:To investigate the expression and clinical significance of FAM83A in lung adenocarcinoma tissue.Methods:The FAM83A mRNA expression data and corresponding clinical data of lung adenocarcinoma patients were downloaded from the Cancer Genome Atlas(TCGA)database, and were divided into para-cancer normal control group and lung adenocarcinoma group. According to the expression level of FAM83A mRNA, the patients with lung adenocarcinoma were divided into FAM83A low expression group and FAM83A high expression group. The relationships of FAM83A mRNA expression with the clinicopathological features and the prognosis of the patients were analyzed.Results:The expression of FAM83A mRNA in the lung adenocarcinoma group was higher than that in the para-cancer normal control group(P=0.001). Between FAM83A low expression group and FAM83A high expression group, there were significant differences in the clinical staging, T and N staging(all P<0.05).The median survival time of FAM83A low expression group and FAM83A high expression group was 1 622 days and 1 357 days,respectively, and the difference was significant(P=0.001).Conclusion:The expression of FAM83A mRNA is increased in lung adenocarcinoma tissue. The high expression of FAM83A mRNA is related to the late stage and prognosis of the patients