维生素D受体基因 rs2222570位点多态性与结核发病相关性的meta分析*
Meta analysis on association between vitamin D receptor gene rs2222570 polymorphisms and tuberculosis risk

目的:判断维生素D受体(VDR)基因rs2222570位点多态性与结核发病风险的关联性。方法:用关键词“维生素D受体多态性”和“结核病”搜索数据库中相关研究,根据各研究间的异质性,使用随机或固定效应模型进行meta分析。最终有20篇文献纳入研究。对基因型以及合并后产生的遗传模型和等位基因多态性与结核发病的相关性进行分析。结果:F 等位基因携带者结核发病风险降低(OR=0.84,95%CI=0.73～0.95); 显性模型遗传模式降低结核发病风险(OR=0.74,95%CI=0.60～0.92)。结论:VDR基因rs2222570位点多态性与结核发病风险有关。
Aim: To determine the association of the vitamin D receptor(VDR)gene rs2222570 polymorphisms with the risk of tuberculosis(TB).Methods: We searched for association studies correlating the VDR polymorphisms and TB using pre-established keywords in Database system. Meta analysis was conducted with random effects model or fixed effects model to account for heterogeneity between studies. Twenty studies were included in the VDR gene rs2222570 meta analysis. Data were analyzed in respect to associations between genotypes, alleles, genetic model and TB.Results: The results of meta analysis showed that the risk of TB was decreased in the F allele carriers(OR=0.84,95%CI=0.73～0.95); among Henan population with dominant models, the risk of TB was lower(OR=0.74,95%CI=0.60～0.92).Conclusion: VDR gene rs2222570 polymorphisms may be associated with the risk of TB