围孕期父母环境危险因素暴露与儿童急性白血病发生风险的关系
Association between parental exposure of periconceptional environmental risk factors and risk of childhood acute leukemia

目的：探讨围孕期父母环境危险因素暴露与儿童急性白血病（CAL）发生风险之间的关系。方法：采用病例对照研究方法，在河南省3家医院募集现治的16岁以下CAL患儿168例；同期同3家医院在呼吸、中医或康复病区募集16岁以下，排除其他肿瘤性、血液性、免疫性疾病的非CAL儿童168例进入对照组，问卷调查患儿及其父母环境危险因素暴露状况，用logistic回归分析筛选CAL发病的危险因素。结果：在控制人口学因素、儿童相关危险因素的影响后，发现母亲孕前6个月/孕期(OR=2.245, 95%CI=1.234~4.087,P=0.008)、父亲孕前6个月(OR=1.864, 95%CI=1.067~3.256,P=0.029)有毒有害化学物质接触是CAL发病的危险因素。结论：围孕期母亲、父亲有毒有害化学物质接触可能会增加CAL发病的风险。
To explore the association between parental exposure of periconceptional environmental risk factors and the risk of childhood acute leukemia(CAL). Methods: According to the design of a case？？control study, 168 cases of CAL under 16 years old were recruited from three hospitals in Henan, as well as 168 children in department of respiration, traditional Chinese medicine or rehabilitation of the same hospitals were recruited as controls, which were excluded suffering with blood and immune system diseases or other tumors. A questionnaire survey was conducted, and logistic regression was used for the data analysis. Results: After controlled the effects of the demographic factors and pediatric？？related environmental risk factors, maternal exposure to chemicals 6 months before pregnancy and/or during pregnancy［OR（95%CI）=2.245(1.234-4.087),P=0.008］, and parental exposure to chemicals 6 months before pregnancy［OR（95%CI）=1.864(1.067-3.256),P=0.029］ were found to be the risk factors of CAL.Conclusion: Parental exposure to harmful or toxic chemicals during periconceptional period may increase the risk of CAL