多系统萎缩患者皮肤组织中泛素和α？餐淮ズ说鞍椎谋泶？*
Expressions of α？？synuclein and ubiquitin in skin tissue of patients with multiple system atrophy

目的：检测多系统萎缩（MSA）患者皮肤组织中泛素（Ub）和α？餐淮ズ说鞍妆泶锏谋浠？，探讨泛素蛋白酶体系统在MSA发病机制中的作用。方法：收集5例MSA患者及8例正常对照的皮肤标本，采用免疫组化法和Western blot方法分别检测Ub及α？餐淮ズ说鞍椎南赴？定位及表达情况。结果：与正常对照组相比，MSA患者皮肤表皮层中Ub［（0.021±0.006） vs （0.429±0.009）］及α？餐淮ズ说鞍祝郏？0.035±0.015） vs （0.111±0.021）］的表达均上调（t=3.974和3.321，P＜0.05）。结论：泛素蛋白酶体系统可能参与了MSA的发病。
To study the function of ubiquitin and α？？synuclein in multiple system atrophy(MSA) patients by the skin biopsy,and to explore the role of ubiquitin proteasome system in the pathogenesis of MSA. Methods: The samples included 5 MSA patients and 8 normal controls. Immunohistochemistry and Western blot were used to detect the expressions of ubiquitin and α？？synuclein in skin tissue. Results: Compared with normal control group,the expressions of ubiquitin［（0.021±0.006） vs （0.429±0.009）］ and α？？synuclein［（0.035±0.015） vs （0.111±0.021）］ in the skin epidermal layer of MSA group were raised(t=3.974,3.321;P<0.05).Conclusion: Ubiquitin proteasome system may be involved in the pathogenesis of MSA