纤维介素2在慢性病毒性肝炎患者中的表达水平及临床意义
The expression and clinical significance of soluble fibrinogen-like protein 2 in patients with chronic viral hepatitis

摘要：目的 探讨可溶性纤维介素2(sFgl2)检测对预测慢性病毒性肝炎患者临床转归和预后的价值。方法 采用ELISA法分别检测85例慢性肝炎患者(42例乙型肝炎和43例丙型肝炎)、108例肝硬化患者(35例乙型肝炎和73例丙型肝炎)及72例健康对照者外周血sFgl2的水平，并与Child-Pugh分级及肝功能指标进行Spearman相关性分析。结果 血清sFgl2水平在肝硬化组显著高于非肝硬化组及健康对照组，且在肝硬化患者中，随Child-Pugh评分升高，外周血sFgl2水平逐渐升高。Spearman相关性分析显示，不考虑病原学，sFgl2水平与TBIL呈正相关，与ALB呈负相关。但与病毒载量、ALT或AST无相关性。结论 证实了外周血sFgl2在肝硬化患者中明显升高，同时发现sFgl2水平与肝硬化患者Child-Pugh分级呈正相关，提示sFgl2水平与肝病严重程度相关，可能成为评估肝硬化患者预后的因素之一。
ABSTRACT: Objective To explore the value of soluble fibrinogen-like protein 2 (sFgl2) assay in predicting clinical outcome and prognosis in patients with chronic viral hepatitis. Methods The level of sFgl2 in serum was tested by ELISA method in 85 patients with chronic hepatitis (42 cases of hepatitis B and 43 ones of hepatitis C), 108 liver cirrhosis patients (35 cases of hepatitis B and 73 ones of hepatitis C), and 72 healthy controls. Spearman correlation was analyzed between sFgl2 level and liver function or Child-Pugh classification. Results The sFgl2 level was significantly higher in liver cirrhosis group than in chronic hepatitis group and healthy controls. As the Child-Pugh score increased, the sFgl2 level of liver cirrhosis patients increased gradually. Regardless of the etiology, the positive relation between sFgl2 with TBIL and negative relation between sFgl2 with ALB could be detected. However, sFgl2 level did not have correlation with viral load or the level of ALT or AST. Conclusion The study further confirmed that serum sFgl2 was significantly elevated in patients with liver cirrhosis and that sFgl2 level was positively correlated with Child-Pugh score. It suggests that sFgl2 level is related to the severity of cirrhosis and may become a tool to evaluate the prognosis of cirrhosis