卵圆孔未闭与无先兆偏头痛患者脑白质病变的比较研究
A comparative study of patent foramen ovale and white matter lesions in migraine without aura

摘要：目的 探讨卵圆孔未闭(PFO)对无先兆偏头痛(MwoA)患者脑白质病变(WMLs)的影响。方法 对35例临床确诊的MwoA患者进行经颅多普勒超声(cTCD)检查及磁共振成像(MRI)检查，根据患者是否合并PFO进行分组，匹配年龄、性别及头痛特征资料，观察磁共振液体衰减反转恢复序列(Flair)图像并比较分析PFO阳性组及阴性组间WMLs差异。结果 MwoA合并PFO 19例，其中WMLs阳性7例，病灶分布于额叶和(或)顶叶，白质评分1～7分；MwoA不合并PFO 16例，其中WMLs阳性5例，病灶亦分布于额叶和(或)顶叶，白质评分1～3分，组间WMLs差异无统计学意义(P>0.05)。结论 MwoA患者的脑白质病变多发生于额、顶叶，尚未发现PFO与MwoA患者的脑白质病变相关。
ABSTRACT: Objective To explore the effect of patent foramen ovale (PFO) on white matter lesions (WMLs) in migraine without aura (MwoA). Methods Thirty-five patients with MwoA were examined by contrast transcranial Doppler (cTCD) and magnetic resonance imaging (MRI). According to the results of PFO and MRI Flair data, the patients’ age, sex and headache characteristics were matched, and the WMLs were compared between the PFO positive group and negative group. Results Seven cases of WMLs were recruited in PFO positive group (19 cases) and the WMLs were distributed in the frontal lobe and/or the parietal lobe. The score ranged from 1 to 7 points. Five cases of WMLs were enrolled in PFO negative group (16 cases) and the WMLs also were distributed in the frontal lobe and/or the parietal lobe. The score ranged from 1 to 3 points. There was no significant difference in WMLs between the groups (P>0.05). Conclusion White matter lesions in migraine without aura are distributed in the frontal lobe and the parietal lobe, and these findings do not support a relationship between PFO and WMLs