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- 2016
慢性心力衰竭患者血清血管生成素-2的表达及临床意义
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Abstract:
摘要：目的 探讨慢性心力衰竭(CHF)患者血清血管生成素-2(Ang-2)的表达水平及临床意义。方法 选择CHF患者113例，对不同心功能分级(NYHA心功能分级：Ⅰ级32例，Ⅱ级30例,Ⅲ级26例,Ⅳ级25例)的CHF患者血清Ang-2、N-末端利钠肽前体(NT-proBNP)和左室射血分数(LVEF)进行检测，并设对照组20例(同期健康体检者)。结果 NYHA心功能Ⅰ级～Ⅳ级的CHF患者，NT-proBNP和Ang-2的表达水平逐渐升高，各组间差异均具有统计学意义(P<0.05)。相关性分析显示，Ang-2与NT-proBNP呈显著的正相关(r=0.774，P<0.001)，Ang-2与LVEF呈显著的负相关(r=-0.725，P<0.001)。结论 Ang-2与心力衰竭严重程度有着明显的相关性，提示其对心力衰竭的诊断及评价预后有一定的临床意义。
ABSTRACT: Objective To investigate the expression of serum angiopoietin-2 (Ang-2) and its clinical significance in patients with chronic heart failure (CHF). Methods The levels of serum Ang-2, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) were detected in 113 patients with CHF, who were divided into four groups according to New York Heart Association (NYHA: class Ⅰ, n=32; Ⅱ, n=30; Ⅲ, n=26; Ⅳ, n=25). Another 20 healthy volunteers for physical check-up were chosen as the control group. Results With the change of cardiac function (from Ⅰ to Ⅳ), the levels of plasma Ang-2 and NT-proBNP were increased significantly (P<0.05). The level of serum Ang-2 was positively correlated with NT-proBNP (r=0.774, P<0.001), but negatively correlated with left ventricular ejection fraction (r=-0.725, P<0.001). Conclusion The level of serum Ang-2 has a significant correlation with the severity of heart failure. Ang-2 is expected to be used to predict and evaluate the severity of CHF
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