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- 2016
分子印迹技术及其在药物分离与分析中的应用
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Abstract:
摘要：复杂体系微量药物和药物相关物质的分离与分析是药学研究领域的共性问题。建立高灵敏度、高选择性、高速度、自动化、连续化、智能化的分析技术是药物分析学科发展的重要方向。新方法的建立对于进一步了解生命过程和药物的作用、保障药品质量、提高药品疗效发挥了积极的推动作用。近年来发展起来的分子印迹技术具有构效预定性、识别特异性、长期稳定性和广泛适用性等特点，得到研究者的广泛关注。本文简述分子印迹技术的原理和制备方法，综述了分子印迹技术在手性药物分析、体内药物分析、中药活性成分和生物大分子的分离与分析等中的应用，并对其面临的问题及应用前景进行了展望。
ABSTRACT: The separation and analysis of trace drugs and drug-related substances in complex systems is a common issue in the field of pharmaceutical research. Establishment of high-sensitivity, high-selectivity, high-speed, automatic, continuous, and intelligent analysis technology is an important direction for the development of pharmaceutical analysis. The establishment of the new method has played a positive role in promoting further understanding of life process and the role of drug effect, guaranteeing drug quality and improving drug efficacy. Molecular imprinting technology (MIT) has attracted wide concern among researchers in recent years because of its characteristics of predetermined structure-activity, recognition specificity, long-term stability and wide applicability. This articles briefly introduces the principles and preparation methods; and reviews the application of MIT in the separation and analysis of chiral drugs, drugs in vivo, the active ingredients of traditional Chinese medicines, and the biomacromolecules. Besides, the problems and future development are also discussed
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