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- 2017
妊娠滋养细胞疾病与“二胎”妊娠
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Abstract:
摘要：随着“二胎”政策全面实施，瘢痕子宫、高龄产妇带来了很多妇科和产科的难题。在重视和应对产科挑战的同时，我们应该同样重视“二胎”妊娠带来的妇科问题，其中葡萄胎发病率升高，可能继发妊娠滋养细胞肿瘤，及妊娠滋养细胞肿瘤患者治疗后的二胎问题，都是目前关注的热点。本文围绕妊娠滋养细胞疾病与“二胎”妊娠的问题，阐述了年龄与妊娠滋养细胞疾病发生发展的关系，化疗对妊娠滋养细胞肿瘤患者卵巢功能的影响，化疗过程中卵巢功能的保护，及治疗后再次妊娠的时机及预后等问题。
ABSTRACT: With the overall implementation of the two-child policy, scar of the uterus and elderly mothers bring a lot of gynecological and obstetric problems. Therefore, we are paying attention and making responses to obstetric challenges. At the same time, we should also attach importance to the gynecological problems caused by the second-birth pregnancy. Currently, the hot spots include increased incidence of hydatidiform mole, which may lead to gestational trophoblastic tumor, and the second-birth pregnancy of gestational trophoblastic tumor patients after treatment. This paper discusses the issues of gestational trophoblastic disease and the second-birth pregnancy from the following aspects: relationship between age and development of gestational trophoblastic disease, effect of chemotherapy on ovarian function in gestational trophoblastic tumor patients, protection of ovarian function during chemotherapy, and appropriate time and prognosis of next pregnancy after treatment
| [1] | IWASE A, SUGITA A, HIROKAWA W, et al. Anti-Müllerian hormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 167(2):194-198. |
| [2] | AYDINER A, KILIC L, YILDIZ I, et al. Two different formulations with equivalent effect? Comparison of serum estradiol suppression with monthly goserelin and trimonthly leuprolide in breast cancer patients[J]. Med Oncol, 2013, 30(1):354. |
| [3] | 全美盈，向阳，万希润，等. 妊娠滋养细胞肿瘤患者化疗后生命质量的相关因素分析[J]. 中华妇产科杂志, 2010, 5(9):673-676. |
| [4] | ZHU HL, WANG Y, LI XP, et al. Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients [J]. Chin Med J, 2013, 126(4):688-691. |
| [5] | VARGAS R, BARROILHET LM, ESSELEN K, et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia:An update from the New England Trophoblastic Disease Center[J]. J Reprod Med, 2014, 59(1):188-194. |
| [6] | RODRIGUEZ N, GOLDSTEIN DP, BERKOWITZ RS. Treating gestational trophoblastic disease[J]. Expert Opin Pharmacother, 2010, 11(18):3027-3039. |
| [7] | TSE KY, CHAN KK, TAM KF, et al. Current management of gestational trophoblastic disease[J]. Obstet Gynaecol Reprod Med, 2014, 25(1):12-21. |
| [8] | RODRIGUEZ-WALLBERG KA, OKTAY K. Fertility preservation during cancer treatment: Clinical guidelines[J]. Cancer Manag Res, 2014, 6(1):105-117. |
| [9] | GOCKLEY AA, MELAMED A, JOSEPH NT, et al. The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy[J]. Gynecol Oncol, 2016, 140(3):470-473. |
| [10] | ELIAS KM, SHONI M, BERNSTEIN M, et al. Complete hydatidiform mole in women aged 40 to 49 years[J]. J Reprod Med, 2012, 57(5-6):254-258. |
| [11] | ELIAS KM, GOLDSTEIN DP, BERKOWITZ RS, et al. Complete hydatidiform mole in women older than age 50[J]. Reprod Med, 2010, 55(5-6):208-212. |
| [12] | RAUH-HAIN JA，GROWDON WB，BRAGA A, et al. Gestational trophoblastic neoplasia in adolescents[J]. J Reprod Med, 2012, 57(5-6):237-242. |
| [13] | RONESS H, KALICH-PHILOSOPH L, MEIROW D. Prevention of chemotherapy-induced ovarian damage: possible roles for hormonal and non-hormonal attenuating agents[J]. Hum Reprod Update, 2014, 20(5):759-774. |
| [14] | 连利娟. 林巧稚妇科肿瘤学[M]. 第4版, 北京：人民卫生出版社, 2006:745. |
| [15] | 向阳. 宋鸿钊滋养细胞肿瘤学[M]. 第3版. 北京: 人民卫生出版社, 2011:4. |
| [16] | LURAIN JR. Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia [J]. Am J Obstet Gynecol, 2011, 204(1):11-18. |
| [17] | SAVAGE PM, SITA-LUMSDEN A, DICKSON S, et al. The relationship of maternal age to molar pregnancy incidence, risks for chemotherapy and subsequent pregnancy outcome[J]. Obstet Gynaecol, 2013, 33(4):406-411. |
| [18] | SAVAGE P, WILLIAMS J, WONG SL, et al. The demographics of molar pregnancies in England and Wales from 2000 to 2009[J]. Reprod Med, 2010, 55(7-8):341-345. |
| [19] | MEIROW D. Reproduction post-chemotherapy in young cancer patients[J]. Mol Cell Endocr, 2000, 169(1):123-131. |
| [20] | JONEBORG U, ELORANTA S, JOHANSSON AL, et al. Hydatidiform mole and subsequent pregnancy outcomes: A population-based cohort study[J]. Am J Obstet Gynecol, 2014, 211(6):681.e1-7. |
