射频热凝靶点消融减压术对腰椎间盘突出症患者血清TNF-α、IFN-γ和IL-17水平的影响
Analgesic effect of radiofrequency ablation on the serum levels of TNF-α, IFN-γ and IL-17 in patients with lumbar disc herniation

摘要：目的 探讨射频热凝靶点消融减压术对腰椎间盘突出症患者血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)和白细胞介素17(IL-17)水平的影响。方法 收集2010年1月至2015年12月在西安交通大学第一附属医院康复医学科入院治疗的腰椎间盘突出症患者276例为试验组，均进行射频热凝靶点消融减压术；选取同期健康体检者133例为对照组。收集住院患者的一般资料和手术前后的血清及对照组血清，ELISA法检测TNF-α、IFN-γ和IL-17水平的变化。结果 腰椎间盘突出症患者血清TNF-α、IFN-γ和IL-17水平明显高于对照组，差异具有统计学意义(P<0.05)；与手术前比较，射频热凝靶点消融减压术后恢复期血清TNF-α、IFN-γ和IL-17水平降低，差异具有统计学意义(P<0.05)。结论 射频热凝靶点消融减压术治疗腰椎间盘突出症不仅能够改善患者疼痛症状，而且能够减轻患者全身炎症反应，值得临床推广应用。
ABSTRACT: Objective To investigate the effect of radiofrequency ablation on serum tumor necrosis factor alpha-α (TNF-α), interferon gamma-γ(IFN-γ) and interleukin 17 (IL-17) levels in patients with lumbar disc herniation. Methods We studied 276 patients with lumbar disc herniation admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2010 to December 2015. The experimental group received radiofrequency thermocoagulation and target ablation decompression treatment. In the same period, 133 healthy subjects were selected as control group. We collected the general information of the admitted patients and their serum before and after operation as well as serum of the control group. The changes of TNF-α, IFN-γ and IL-17 levels were detected by ELISA method. Results The levels of serum TNF-α, IFN-γ and IL-17 in the patients with lumbar disc herniation were significantly higher than those in the control group (P<0.05). Compared with those before operation, the serum levels of TNF-α, IFN-γ and IL-17 were decreased significantly in the recovery phase after radiofrequency ablation (P<0.05). Conclusion Frequency thermal coagulation target ablation decompression treatment of lumbar disc herniation can not only improve pain symptoms but also reduce the systemic inflammatory reactions. Therefore, it deserves clinical application