甲状腺结节与代谢综合征相关组分的临床研究
Correlation between thyroid nodules and the components of metabolic syndrome

摘要：目的 了解西安地区体检人群甲状腺结节的超声检出情况，探讨甲状腺结节的发生与代谢综合征各组分间的相关性。方法 采用横断面调查方法搜集我院体检部4527名体检者的资料，按超声结果将体检者分为甲状腺结节组和非甲状腺结节组，采集两组人群的病史、身高、体质量、血压、空腹血糖、血脂、血尿酸等资料并做统计学分析，检测TT3、TT4、TSH、TGAB、TPOAB以评估甲状腺结节与甲状腺功能的关系。结果 ①甲状腺结节患病率为31.8%，女性患病率明显高于男性(38.4% vs. 27.1%，χ2=64.44，P<0.001)；代谢综合征患病率为9.1%，男性患病率明显高于女性(11.4% vs. 5.9%，χ2=40.39，P<0.001)。②与非甲状腺结节者相比，甲状腺结节患者仅TT3明显升高(t=6.04，P<0.001)，而TT4、TSH、TGAB、TPOAB的水平均未见统计学差异(P>0.05)。③甲状腺结节者年龄、收缩压、TG、LDL-C及尿酸水平均显著高于非甲状腺结节者(P<0.001)。结论 西安地区体检人群甲状腺结节患病率较高，高收缩压、血脂异常及高尿酸水平均与甲状腺结节具有一定的相关性，应加强此类人群甲状腺结节的筛查及管理。
ABSTRACT: Objective To investigate the prevalence of thyroid nodules in Xi’an City by ultrasonography and study the correlation between thyroid nodules and the components of metabolic syndrome. Methods We recruited 4527 subjects in this cross-sectional study and divided them into thyroid nodules (TN) group and non-thyroid nodules (NTN) group. The height, weight, blood pressure, blood sugar, lipid, and serum uric acid were measured and analyzed. The relationship between thyroid nodules and thyroid function was assessed in the subjects who received TT3, TT4, TSH, TGAB, and TPOAB tests. Results ① The prevalence of thyroid nodules was 31.8% and was significantly higher in the female patients (38.4% vs. 27.1%, χ2=64.44，P<0.001). However, the prevalence of metabolic syndrome was 9.1% and was significantly higher in the male ones (11.4% vs. 5.9%, χ2=40.39, P<0.001). ② Compared with that in NTN group, TT3 in TN group was significantly increased (t=6.04, P<0.001), but the other indexes did not obviously change in the two groups (P>0.05). ③ Age, systolic blood pressure, and TG, LDL-C and serum uric acid levels were remarkably higher in TN group than in NTN group (P<0.001). Conclusion The prevalence of thyroid nodules in Xi’an City is noticeably high. High systolic blood pressure level, dyslipidemia and elevated uric acid are associated with thyroid nodules. Therefore, screening and management of the individuals with aforementioned characteristics deserve more attention