不同过敏原检测方法在结节性痒疹患者中的应用
Allergens detection and clinical analysis of prurigo nodularis in patients

摘要：目的 为结节性痒疹(PN)患者过敏原检测方法的选择提供临床依据，并进一步研究PN过敏原的分布特征。方法 PN患者262例分4组进行点刺试验(54例)、斑贴试验(50例)、血清IgE过敏原检测(56例)和血清IgG过敏原检测(102例)，系统分析PN患者各项过敏原阳性率和分布差异。结果 与对照组比较，54例PN患者点刺试验中法桐、艾蒿、杨树、粉尘螨、屋尘螨、鳕鱼、花生和番茄的阳性率增高(P<0.05)；50例PN患者斑贴试验中硫酸镍、芳香混合物、黑橡胶混合物和卡巴混合物阳性率增高(P<0.05)；56例PN患者血清IgE试验中屋尘、？草、猫毛/狗毛、蟑螂、青霉/孢霉和羊肉阳性率增高(P<0.05)；102例PN患者血清IgG试验中蟹、虾、牛肉、鳕鱼阳性率增高(P<0.05)。结论 点刺试验、血清IgE检测在PN患者中的应用非常重要，血清IgG检测对PN患者饮食结构的调整也有一定意义，而斑贴试验在PN中的应用意义还需要进一步探讨。
ABSTRACT: Objective To investigate the distributional characteristics of anaphylactogens in prurigo nodularis (PN) patients so as to provide clinical basis for selecting the method of allergy test.Methods We divided 262 PN patients into four groups and then used skin-prick (54 patients), skin-patch (50 patients), serum IgE allergen detection (56 patients) and serum IgG allergen detection (102 patients) to analyze anaphylactogen positive rate and their distribution differences in PN. Results For skin-prick test in 54 PN patients, the detection rates of platanus orientalis, artemisia argyi, poplar, dust mite, dirt mite, cod, peanut and tomato were higher than those in the control group (P<0.05). For skin-patch test in 50 PN patients, the detection rates of nickel sulfate, flavor compounds, black rubber, and carba mix were higher than those in the control group (P<0.05). For serum IgE test in 56 PN patients, the detection rates of house dust, scandent hop, cat/dog hair, bug, penicillium/neurospora and mutton were higher than those in the control group (P<0.05). For serum IgG test in 102 PN ones, the detection rates of crab, shrimp, beef and cod were higher than those in the control group (P<0.05). Conclusion Skin-prick test and serum IgE detection have high application values in PN patients. Serum IgG detection is of certain importance in adjusting PN patients’ diet structure while skin-patch test applied in PN needs further exploration