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- 2017
孕产妇不良妊娠结局危险因素的病例对照研究
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Abstract:
摘要：目的 探讨孕产妇不良妊娠结局的危险因素。方法 采用以医院为基础的非匹配病例对照研究，收集产妇的一般情况、既往生育史、孕期异常状况及患病等资料，使用单因素χ2和多因素非条件Logistic回归进行分析。结果 单因素χ2显示，文化程度高是不良妊娠结局可能的保护因素，高龄产妇、工作体力强度大、怀孕次数多、有自然流产史、早孕反应程度重、孕期有疾病史、孕前有疾病史为不良妊娠结局可能的危险因素；多因素非条件Logistic回归分析表明，文化程度高(OR=0.63，95% CI：0.50～0.80)是不良妊娠结局的保护因素，早孕反应程度重(OR=2.13，95% CI：1.63～2.79)、孕前有疾病史(OR=2.25，95% CI：1.06～4.77)是不良妊娠结局的危险因素。结论 提高孕产妇文化水平，重视严重早孕反应的宣教预防和全面彻底治疗，鼓励新婚夫妇进行婚前和孕前体检，有针对性地对不同身体状况的产妇进行孕期保健指导，将有效降低不良妊娠结局的发生。
ABSTRACT: Objective To explore the risk factors for maternal adverse pregnancy outcomes. Methods An unmatched case-control study based on hospital was performed. Univariate and multivariate Logistic regression were used to analyze the related factors of maternal adverse pregnancy outcomes, including general condition, history of fertility, abnormal symptoms and diseases during pregnancy. Results Univariate analysis results showed that high education level of gravida might be the protective factors of adverse pregnancy outcomes. The risk factors for adverse pregnancy outcome might include advanced maternal age, intensive workload, frequent pregnancy, history of spontaneous abortion, severe morning sickness, and sickness during pregnancy or progestation. Multivariate Logistic regression analysis showed that high education level of gravida (OR=0.63, 95% CI: 0.50-0.80) was the protective factor of adverse pregnancy outcomes; severe morning sickness (OR=2.13, 95% CI: 1.63-2.79) and sickness during progestation (OR=2.25, 95% CI: 1.06-4.77) were the risk factors for maternal adverse pregnancy outcomes. Conclusion The level of maternal education should be improved. We should attach great importance to preventive education and thorough treatment of severe morning sickness. Couples should be encouraged to have physical examination before marriage and pregnancy. Corresponding pregnancy care guidance should be given to pregnant women with different physical conditions so as to effectively reduce the occurrence of adverse pregnancy outcomes
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