神经电生理监测在腰骶部椎管内肿瘤显微切除术中的应用
Application of intraoperative nerve electrophysiological monitoring inlumbosacral spinal cord tumor resection

摘要：目的 探讨神经电生理监测在腰骶部椎管内肿瘤切除术中的应用价值。方法 回顾性分析2005年1月～2015年1月西安交通大学第一附属医院神经外科手术治疗的212例腰骶部椎管内肿瘤患者的临床资料。所有患者均由同一治疗组在显微镜操作下行肿瘤切除术，肿瘤部位均位于L1以下。其中124例行术中电生理监测(监测组)，监测方法为皮质躯体感觉诱发电位(CSEP)、皮节体感诱发电位(DSEP)和肌电图(EMG)联合，88例未行术中电生理监测(未监测组)，两组患者均随访3～6个月；对两组患者预后改善情况进行统计学分析。结果 监测组的改善率及全切除率高于未监测组(P<0.05)，联合应用CSEP、DSEP和EMG的敏感性为100%，特异性为55.9%，DSEP较CSEP有更高的敏感性。结论 联合应用CSEP+DSEP+EMG对于腰骶部椎管内肿瘤切除术中神经根的保护及提高手术安全性有重要的应用价值。
ABSTRACT: Objective To study intraoperative neural electrophysiological monitoring applied in lumbosacral spinal cord tumor resection. Methods We retrospectively reviewed the clinical data of 212 patients undergoing lumbosacral spinal cord tumor resection with or without intraoperative neural electrophysiological monitoring in our hospital. The patients were divided into two groups: 124 patients in the monitored group received intraoperative neural electrophysiological monitoring while 88 ones in the control group did not. The monitoring was performed by recording the cortical somatosensory evoked potential (CSEP), dermatomal somatosensory evoked potential (DSEP) and electromyography (EMG). The patients were followed up for 3-6 months and their postoperative outcome was analyzed. Results There were significant differences in the outcome (P<0.05), but no difference was found in the incidence of complications between the monitored group and the control group. The sensitivity of CSEP +DSEP+EMG was 100%, and the specificity was 55.9% in the former group. Conclusion Combined monitoring with CSEP, DSEP and EMG during lumbosacral spinal cord tumor resection is valuable in protecting the spinal nerve roots and ensuring better operation safety