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- 2017
基于倾向值匹配的孕早期感染与子代循环系统先天性畸形的关系
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Abstract:
摘要：目的 探讨孕早期感染与子代循环系统先天性畸形的关系。方法 在西安市6家三甲医院收集循环系统先天性畸形胎儿/新生儿和正常新生儿共计1618例，通过问卷调查收集母亲孕期相关信息；采用倾向值匹配的方法，对孕早期未感染组和孕早期感染组进行1∶1匹配后分析。结果 对两组间进行倾向值匹配后，所有混杂因素均在两组间达到平衡。匹配后孕早期感染母亲子代发生循环系统先天畸性是孕早期未感染母亲子代的1.65倍(95% CI：1.21～2.24；P=0.001)；匹配后孕早期感染母亲子代发生单一循环系统先天畸性是孕早期未感染母亲子代的1.50倍(95% CI：1.02～2.20；P=0.037)；匹配后孕早期感染母亲子代发生复杂循环系统先天畸性是孕早期未感染母亲子代的1.90倍(95% CI：1.18～3.06；P=0.008)。结论 母亲孕早期感染增加子代循环系统先天性畸形的发生，在孕早期应尽量避免发生感染性疾病，减少子代循环系统先天性心脏病的发生。
ABSTRACT: Objective To explore the relationship between first trimester pregnancy infection and congenital malformation in the cardiovascular system. Methods A hospital-based study was conducted from June 2014 to June 2016. Totally 1618 mothers of infants with cardiovascular system malformation and normal infants were interviewed through a face-to-face questionnaire survey. A propensity score-matched study was conducted to investigate the association between first trimester pregnancy infection and congenital malformation in the cardiovascular system. Results All important covariates were balanced after matching. First trimester pregnancy infection increased the risk of congenital malformation in the cardiovascular system, single congenital malformation in the cardiovascular system and multi-congenital malformation in the cardiovascular system. After matched, the OR values were 1.65 (95% CI: 1.21-2.24; P=0.001), 1.50 (95% CI: 1.02-2.20; P=0.037), and 1.90 (95% CI: 1.18-3.06; P=0.008), respectively. Conclusion First trimester pregnancy infection increases the risk of congenital malformation in the cardiovascular system. Avoiding infectious diseases during the first trimester in pregnancy is important in decreasing the incidence of congenital malformation in the cardiovascular system
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