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- 2017
心力衰竭中枢发病机制的研究进展
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Abstract:
摘要：心力衰竭(简称心衰)是一种复杂的临床综合征，任何心室结构或功能受损所导致的充盈障碍或射血障碍均可引起心力衰竭。发达国家成年人群心力衰竭患病率达到1%～2%，而70岁以上的老年人群患病率升高到≥10%。随着人口的老龄化以及冠心病患病率的增加，心力衰竭患病率有上升趋势，并且已经成为人类致残、致死的重要疾病。心衰受到体内各种神经体液因素的调节，中枢神经激素如：肾素-血管紧张素系统(renin-angiotensin system, RAS)、炎性细胞因子(proinflammatory cytokines, PIC)、活性氧簇(reactive oxygen species, ROS)等的改变可能与心衰中枢活动增强密切相关，并可以明显改变外周交感神经的活动。持续的交感神经活动增强是心衰发生发展的重要原因，因此降低交感神经兴奋性成为心衰治疗研究的焦点之一。本文着重论述中枢神经激素对心衰的影响和可能的中枢调控机制。
ABSTRACT: Heart failure is a complex clinical syndrome, and impaired filling or ejection disorders result from any ventricular structure or dysfunction can cause heart failure. The prevalence of heart failure in adult populations in developed countries has reached 1% to 2%, while the prevalence in elderly people over 70 years of age has increased to ≥10%. With the population aging and the prevalence of coronary heart disease increased, the prevalence of heart failure has increased, becoming a disable and fatal disease. The changes of the central nervous system hormones such as renin-angiotensin system (RAS), inflammatory cytokines (proinflammatory cytokines, PIC), and reactive oxygen species (ROS) may be closely related to increased central activity in heart failure, which can significantly alter the activities of peripheral sympathetic nerves. Constant sympathetic nervous activity is an important cause of development of heart failure, so reducing the sympathetic excitability of heart failure is regarded as one of the focuses of treatment and research. This paper focuses on the influence of central neurohormone on heart failure and possible central mechanism
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