CD146和TfR1在上皮性卵巢癌中的表达及临床意义
Expressions and clinical significance of CD146 and TfR1 in ovarian epithelial cancer

摘要：目的 检测细胞黏附分子CD146及转铁蛋白受体(TfR1)在上皮性卵巢癌的表达，探讨其与上皮性卵巢癌临床病理学特征的关系，进一步了解上皮性卵巢癌的发病机制。方法 采用免疫组化方法，检测正常卵巢组织、卵巢上皮性良性肿瘤及上皮性卵巢癌中CD146和TfR1的表达。结果 CD146及TfR1的表达水平随着正常、良性及恶性上皮性卵巢肿瘤组织的变化而升高，各组间差异有统计学意义(P<0.05)；CD146及TfR1的阳性表达率随着上皮性卵巢癌国际妇科联盟(FIGO)分期升高、组织学分化程度降低而升高(P<0.05)；与年龄及病理类型均无关(P<0.05)。在上皮性卵巢癌中，CD146、TfR1蛋白的阳性表达率间呈正相关(P<0.05，rs=0.532)。二者联合检测的敏感度为82.4%，特异性为75.0%。结论 CD146和TfR1的高表达与上皮性卵巢癌的发生、发展及转移有关，CD146和TfR1联合检测可以作为其诊断和判断预后的指标，并为上皮性卵巢癌的靶向治疗提供可能。
ABSTRACT: Objective To evaluate the expressions of cell adhesion molecules CD146 and transferrin receptor 1 (TfR1) in ovarian epithelial cancer and investigate their relationship with clinical pathological features of patients with ovarian epithelial cancer (OEC) so as to further explore the pathogenesis of OEC. Methods Immunohistochemistry was employed to determine the expressions of CD146 and TfR1 in normal, benign and ovarian cancer tissues. Results The immunohistochemical results showed that the positive expressions of CD146 and TfR1 gradually increased with the changes of normal, benign and malignant tissues in OEC. There were significant differences between all the groups (P<0.05). The advanced the clinical stage, the higher the expression rate (P<0.05). The lower the histopathological differentiation, the higher the expression rate (P<0.05). The expressions of CD146 and TfR1 were not correlated with age or pathological patterns (P>0.05). There was a significant correlation between expressions of CD146 and TfR1 in OEC (P<0.05, rs=0.532). Combined detection sensitivity and specificity were 82.4% and 75.0%. Conclusion The high expressions of CD146 and TfR1 may play a key role in the occurrance, progression and metastasis of OEC. They may be used as potential markers for diagnosis, postoperative follow-up and targeted therapy