全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

用于生物型人工肝脏支持系统的肝细胞状态检测及应用进展

DOI: doi:10.7507/1001-5515.201705066

Keywords: 生物型人工肝脏支持系统, 生物反应器, 肝细胞状态, 检测指标, 检测方法

Full-Text   Cite this paper   Add to My Lib

Abstract:

生物型人工肝脏支持系统(BALSS)具有肝脏的解毒、提供营养及改善内环境等功能,为治疗肝功能衰竭提供了新方法,也为患者等待肝移植争取了时间。生物反应器和具有良好生物活性的肝细胞是 BALSS 的核心,决定着治疗效果。在长时间的治疗过程中,肝细胞的功能活性会产生较大变化,因此为保证 BALSS 的治疗效果,检测肝细胞状态十分重要。本文介绍了表征细胞损伤程度、解毒功能以及合成功能这三方面的指标及其常用检测方法,总结了细胞状态检测技术在 BALSS 中的应用并讨论了其发展趋势

References

[1]  25. 姜春华. 人工肝支持系统在肝功能衰竭中的应用进展. 临床合理用药杂志, 2017, 10(3C): 171-172.
[2]  26. Struecker B, Raschzok N, Sauer I M. Liver support strategies: cutting-edge technologies. Nat Rev Gastroenterol Hepatol, 2014, 11(3): 166-176.
[3]  27. Nibourg G A, Hoekstra R, van der Hoeven T V, et al. Increased hepatic functionality of the human hepatoma cell line HepaRG cultured in the AMC bioreactor. International Journal of Biochemistry & Cell Biology, 2013, 45(8): 1860-1868.
[4]  28. 高义萌, 孙露露, 惠利健. 生物人工肝研究进展. 生命科学, 2016, 28(8): 915-920.
[5]  29. 郭欢, 邵安良, 程祥, 等. 生物人工肝用海藻酸钠/壳聚糖微囊的安全性和生物功能评价. 药物分析杂志, 2016, 36(1): 36-45.
[6]  30. Damania A, Kumar A, Sarin S K, et al. Optimized performance of the integrated hepatic cell-loaded cryogel-based bioreactor with intermittent perfusion of acute liver failure plasma. J Biomed Mater Res B Appl Biomater, 2017, 1: 1-11.
[7]  31. Wang Gang, Feng Enmin, Xiu Zhilong. Modeling and parameter identification of microbial bioconversion in fed-batch cultures. J Process Control, 2008, 18(5): 458-464.
[8]  32. Hollmann M, Boertz J, Dopp E, et al. Parallel on-line detection of a methylbismuth species by hyphenated GC/EI-MS/ICP-MS technique as evidence for bismuth methylation by human hepatic cells. Metallomics, 2010, 2(1): 52-56.
[9]  33. 郭庆强, 林建强, 李歧强. 微生物发酵过程的细胞密度在线检测与底物浓度实时控制. 中国科学技术大学学报, 2012, 42(7): 584-589.
[10]  34. Murray N P, Fuentealba C, Reyes E, et al. A comparison of 3 on-line nomograms with the detection of primary circulating prostate cells to predict prostate cancer at initial biopsy. Actas Urol Esp, 2017, 41(4): 234.
[11]  35. 项红升, 刘剑峰, 李明, 等. 生物型人工肝的在线快速细胞监测系统. 生物医学工程与临床, 2005, 9(1): 45-48.
[12]  36. Tan S J, Lakshmi R L, Chen Pengfei, et al. Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients. Biosens Bioelectron, 2010, 26(4, SI): 1701-1705.
[13]  37. Sequist L V, Nagrath S, Toner M, et al. The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients. J Thorac Oncol, 2009, 4(3): 281-283.
[14]  38. 修小青, 霍小林, 李明, 等. 生物人工肝细胞状态在线微检测系统的研究. 现代科学仪器, 2009, 8(4): 11-14.
[15]  39. Cao Y, Wu C Z, Huo X L, et al. Design and simulation of a novel micro-mixer for detecting cell status in bio-artificial liver. Appl Mech Mater, 2012, 246-247: 241-245.
[16]  40. Wu Changzhe, Cao Yue, Huo Xiaolin, et al. Simulation and experimental research on micro-channel for detecting cell status in bio-artificial liver. Technol Health Care, 2015, 23(Suppl 2): S365-S371.
[17]  41. 方云, 汤治元, 张倩, 等. 人肝癌细胞电阻抗特性的实验研究. 生物医学工程学杂志, 2014, 31(5): 1070-1074.
[18]  42. Emma P, Kamen A. Real-time monitoring of influenza virus production kinetics in HEK293 cell cultures. Biotechnol Prog, 2013, 29(1): 275-284.
[19]  1. 王英杰. 生物人工肝. 北京: 人民卫生出版社, 2002.
[20]  2. Han Bing, Shi Xiaolei, Zhang Yue, et al. Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study. Eur J Med Res, 2012, 17: 13.
[21]  3. Ba?ares R, Catalina M V, Vaquero J. Molecular adsorbent recirculating system and bioartificial devices for liver failure. Clin Liver Dis, 2014, 18(4): 945-956.
[22]  4. Nicolas C T, Hickey R D, Chen H S, et al. Concise review: liver regenerative medicine: from hepatocyte transplantation to bioartificial livers and bioengineered grafts. Stem Cells, 2017, 35(1): 42-50.
[23]  5. 陈煜, 李爽. 人工肝支持系统的临床应用. 临床荟萃, 2016, 31(7): 717-722.
[24]  6. 鲁艳玲, 张晓娟, 马建奇, 等. 血浆置换联合血液灌流治疗肝衰竭的疗效观察. 疑难病杂志, 2015, 14(3): 254-257.
[25]  7. van Wenum M, Chamuleau R AFM, van Gulik T M, et al. Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications. Expert Opin Biol Ther, 2014, 14(12): 1745-1760.
[26]  8. Yu Chengbo, Pan Xiaoping, Yu Liang, et al. Evaluation of a novel choanoid fluidized bed bioreactor for future bioartificial livers. World Journal of Gastroenterology, 2014, 20(22): 6869-6877.
[27]  9. Poyck P P C, Hoekstra R, Chhatta A, et al. Time-related analysis of metabolic liver functions, cellular morphology, and gene expression of hepatocytes cultured in the bioartificial liver of the Academic Medical Center in Amsterdam (AMC-BAL). Tissue Eng, 2007, 13(6): 1235-1246.
[28]  10. Sussman N L, Kelly J H. Artificial liver. Clin Gastroenterol Hepatol, 2014, 12: 1439-1442.
[29]  11. Zhang Zhi, Zhao Yichao, Cheng Yuan, et al. Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure. World J Gastroenterol, 2014, 20(46): 17399-17406.
[30]  12. Shi Xiaolei, Gao Yimeng, Yan Yupeng, et al. Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Res, 2016, 26(2): 206-216.
[31]  13. Liu Yuhan, Lu Keding, Dong Huabin, et al. In situ monitoring of atmospheric nitrous acid based on multi-pumping flow system and liquid waveguide capillary cell. J Environ Sci (China), 2016, 43: 273-284.
[32]  14. 高景波, 王雪妹, 韦旭, 等. 血站实验室 ALT 检测性能验证方法的探讨. 中国输血杂志, 2015, 28(9): 1094-1097.
[33]  15. 汪辛如. 干化学法与速率法在不同血液样本 ALT 检测中的应用. 临床输血与检验, 2014, 16(1): 61-63.
[34]  16. 黄腊梅. 巴中市无偿献血者丙氨酸氨基转移酶检测结果研究. 检验医学与临床, 2016, 13(4): 524-525.
[35]  17. 马静瑶. 干化学法和速率法在献血前 ALT 筛查中的应用比较. 临床医学研究与实践, 2017, 2(6): 164-165.
[36]  18. 李建元. 游泳池水中尿素的两种测定方法比较. 中国卫生检验杂志, 2011, 21(3): 763-764.
[37]  19. 李俊华. 酶法尿素检测试剂的改进及性能评价. 检验医学, 2014, 29(4): 390-393.
[38]  20. 周小微, 李安全. 血清抗体与快速尿素酶检测幽门螺杆菌感染的灵敏度及特异性分析. 现代医药卫生, 2016, 32(22): 3502-3503.
[39]  21. 黄报亮, 吴清平, 邓金花, 等. 尿素检测方法的研究进展及其快速检测产品现状. 光谱实验室, 2013, 30(5): 2565-2571.
[40]  22. Hassnein W A, Uluer M C, Woodall J D, et al. Bio-Artificial liver generation using multilineage xenogenic and heterogenic cells. J Am Coll Surg, 2016, 223(4, Suppl 2): e50.
[41]  23. 唐海涛. 白蛋白稀释液联合 706 代血浆在人工肝治疗乙型肝功能衰竭中的疗效观察. 临床医药文献电子杂志, 2016, 3(25): 5086-5087.
[42]  24. 柯柳华, 孙一帆, 潘红梅. 血清前白蛋白和白蛋白在 196 例肝病患者中的检测分析. 中国民族民间医药, 2014(23): 92-94.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133