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-  2015 

表观遗传学对骨髓间充质干细胞调控作用的研究进展

DOI: doi:10.7507/1001-5515.20150123

Keywords: DNA甲基化, 组蛋白乙酰化, 小干扰RNA, 微小RNA, 骨髓间充质干细胞

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Abstract:

表观遗传学对骨髓间充质干细胞的调控作用已经成为医学领域的研究热点。本文主要综述了DNA甲基化、组蛋白乙酰化、小干扰RNA(siRNA)诱导基因沉默以及微小RNA(miRNA)四个方面对骨髓间充质干细胞调控作用的进展。结果表明, 表观遗传学对骨髓间充质干细胞的调控作用在骨修复、神经修复和心肌修复等方面的应用具有重要的意义

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