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-  2017 

羟基磷灰石/磷酸三钙生物材料植入小鼠体内的血管化过程

DOI: doi:10.7507/1001-5515.201601007

Keywords: 羟基磷灰石/磷酸三钙, 血管化, 骨诱导, 骨组织工程

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Abstract:

本研究旨在探讨羟基磷灰石/磷酸三钙(HA/TCP)生物陶瓷材料植入小鼠体内骨诱导过程中新生血管的形成过程。将 HA/TCP 材料植入小鼠肌肉中,手术后 2、4、6、8、10 和 12 周,收获材料制备连续切片,通过观察 HE 染色图片动态描述新生血管形成过程,并定量分析新生血管形成百分比。结果显示新生血管形成是一个连续、动态的过程,其在第 2 周时就大量生成,4 周时呈增长趋势,6 周时达到峰值,8 周后逐步减少。本研究结果为提高骨组织工程成功率提供了思路,也从血管化方面揭示了骨诱导形成的机制

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