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-  2018 

吸烟成瘾者戒烟前后的静息态功能磁共振研究

DOI: doi:10.7507/1001-5515.201609026

Keywords: 静息态, 功能磁共振成像, 戒烟, 局域一致性

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Abstract:

为了发现吸烟成瘾者在戒烟前后的脑功能特征改变,探索戒烟过程的神经生理理论基础,14 名吸烟成瘾者同意戒烟并完成了试验,另外 11 名健康不吸烟的志愿者参与了对照试验。采取两因素混合实验设计方法,以静息态功能磁共振影像技术为技术手段,利用区域一致性算法来研究吸烟成瘾者在戒烟前后的神经活动及其与正常人之间的差异,并对这些差异进行组内与组间交互分析。戒烟两周后,在补充运动区、中央旁小叶、距状裂周围皮层、楔叶和舌回等区域的 ReHo 值明显上升,意味着在这些脑区的神经活动同步性增强,而在楔前叶和后扣带回脑区同步性降低。在补充运动区、中央旁小叶、中央前回、中央后回、眶部额上回等脑区存在组间交叉效应。本研究结果显示吸烟成瘾者戒烟 2 周后在补充运动区的功能显著增强

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