全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

注意缺陷多动障碍儿童自发脑活动的多参数静息态功能磁共振研究

DOI: doi:10.7507/1001-5515.201801001

Keywords: 注意缺陷多动障碍, 功能磁共振成像, 局部一致性, 度中心性, 镜像同伦功能连接

Full-Text   Cite this paper   Add to My Lib

Abstract:

注意缺陷多动障碍(ADHD)儿童的大脑功能异常已经被广泛报道,但是其结果存在不一致性,且半球间功能连接相关研究较少。本研究纳入了 45 名首发未用药 ADHD 儿童和 26 名正常对照儿童,进行静息态功能磁共振扫描。采用局部一致性(ReHo)、度中心性(DC)和镜像同伦功能连接(VMHC)三种测量指标对两组受试的静息态脑活动进行比较分析。发现与正常儿童相比,ADHD 儿童 ReHo 值和 DC 值在右侧额中回区域降低,且两者呈正相关;VMHC 值在双侧枕叶降低,且该改变与 Conners 父母用量表焦虑得分呈负相关,与威斯康星卡片测验正确分类数呈正相关。本研究结果提示了 ADHD 儿童右侧额中回及双侧枕叶自发神经活动的异常

References

[1]  1. Barkley R A, Biederman J. Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry, 1997, 36(9): 1204-1210.
[2]  9. Zuo X N, Ehmke R, Mennes M, et al. Network centrality in the human functional connectome. Cereb Cortex, 2012, 22(8): 1862-1875.
[3]  10. Zuo X N, Kelly C, Di Martino A, et al. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci, 2010, 30(45): 15034-15043.
[4]  11. Park B Y, Hong J, Lee S H, et al. Functional connectivity of child and adolescent attention deficit hyperactivity disorder patients: correlation with IQ. Front Hum Neurosci, 2016, 10: 565.
[5]  12. Park B Y, Park H. Connectivity differences between adult male and female patients with attention deficit hyperactivity disorder according to resting-state functional MRI. Neural Regen Res, 2016, 11(1): 119-125.
[6]  14. Zhu Chaozhe, Zang Yufeng, Cao Qingjiu, et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage, 2008, 40(1): 110-120.
[7]  15. Yang Hong, Wu Qizhu, Guo Lanting, et al. Abnormal spontaneous brain activity in medication-na?ve ADHD children: a resting state fMRI study. Neurosci Lett, 2011, 502(2): 89-93.
[8]  17. Zang Yufeng, Jiang Tianzi, Lu Yingli, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
[9]  19. Cheng Wei, Ji Xiaoxi, Zhang Jie, et al. Individual classification of ADHD patients by integrating multiscale neuroimaging markers and advanced pattern recognition techniques. Front Syst Neurosci, 2012, 6: 58.
[10]  22. Cao Qingjiu, Zang Yufeng, Sun Li, et al. Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport, 2006, 17(10): 1033-1036.
[11]  24. Yan Chaogan, Yang Zhen, Colcombe S J, et al. Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics. Sci Bull, 2017, 62(23): 1572-1584.
[12]  26. 杨润许, 丁凯景, 刘瑞湘, 等. 注意缺陷多动障碍儿童的静息态脑功能磁共振研究. 中国当代儿科杂志, 2013, 15(9): 723-727.
[13]  28. Zhang Jie, Kendrick K M, LU Guangming, et al. The fault Lies on the other side: altered brain functional connectivity in psychiatric disorders is mainly caused by counterpart regions in the opposite hemisphere. Cereb Cortex, 2015, 25(10): 3475-3486.
[14]  3. 童连, 史慧静, 臧嘉捷. 中国儿童ADHD流行状况Meta分析. 中国公共卫生, 2013, 29(9): 1279-1283.
[15]  4. Faraone S V, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med, 2006, 36(2): 159-165.
[16]  5. Castellanos F X, Aoki Y. Intrinsic functional connectivity in attention-deficit/hyperactivity disorder: A science in development. Biol Psychiatry Cogn Neurosci Neuroimaging, 2016, 1(3): 253-261.
[17]  6. 郭润蒲, 杜亚松. 注意缺陷多动障碍相关脑网络结构及功能磁共振研究进展. 中国神经精神疾病杂志, 2016, 42(9): 556-559.
[18]  2. Polanczyk G, de Lima M S, Horta B L, et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry, 2007, 164(6): 942-948.
[19]  7. Barkhof F, Haller S, Rombouts S A. Resting-state functional MR imaging: a new window to the brain. Radiology, 2014, 272(1): 29-49.
[20]  8. Beckmann C F, Deluca M, Devlin J T, et al. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci, 2005, 360(1457): 1001-1013.
[21]  13. Di Martino A, Zuo X N, Kelly C, et al. Shared and distinct intrinsic functional network centrality in autism and attention-deficit/hyperactivity disorder. Biol Psychiatry, 2013, 74(8): 623-632.
[22]  16. Zang Yufeng, He Yong, Zhu Chaozhe, et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev, 2007, 29(2): 83-91.
[23]  18. An Li, Cao Qingjiu, Sui Manqiu, et al. Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study. Neurosci Bull, 2013, 29(5): 603-613.
[24]  20. Liu Dongqiang, Yan Chaogan, Ren Juejing, et al. Using coherence to measure regional homogeneity of resting-state FMRI signal. Front Syst Neurosci, 2010, 4: 24.
[25]  21. An Li, Cao Xiaohua, Cao Qingjiu, et al. Methylphenidate normalizes resting-state brain dysfunction in boys with attention deficit hyperactivity disorder. Neuropsychopharmacology, 2013, 38(7): 1287-1295.
[26]  23. Alonso Bde D, Hidalgo Tobón S, Dies Suarez P, et al. A multi-methodological MR resting state network analysis to assess the changes in brain physiology of children with ADHD. PLoS One, 2014, 9(6): e99119.
[27]  25. Yu Xiaoyan, Yuan Binke, Cao Qingjiu, et al. Frequency-specific abnormalities in regional homogeneity among children with attention deficit hyperactivity disorder: a resting-state fMRI study. Sci Bull, 2016, 61(9): 682-692.
[28]  27. Golestani A M, Goodyear B G. Regions of interest for resting-state fMRI analysis determined by inter-voxel cross-correlation. NeuroImage, 2011, 56(1): 246-251.
[29]  29. Chen Lizhou, Hu Xinyu, Ouyang Luo, et al. A systematic review and meta-analysis of tract-based spatial statistics studies regarding attention-deficit/hyperactivity disorder. Neurosci Biobehav Rev, 2016, 68: 838-847.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133