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-  2018 

低频重复经颅磁刺激对孤独症儿童脑电节律的影响

DOI: doi:10.7507/1001-5515.201707001

Keywords: 孤独症, 相对功率, 相干性, 脑电

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Abstract:

孤独症谱系障碍(ASD)是一种涉及多种神经系统的复杂发育障碍性疾病,主要表现为社交沟通障碍以及刻板行为。脑电图(EEG)测量与皮层突触活动相关的神经电生理变化,对检查者无损伤,已被证明是检测神经疾病的有力工具。为深入研究低频重复经颅磁刺激(rTMS)应用于 ASD 患者康复的作用,本文招募 32 名 ASD 被试,其中 16 名 ASD 患者作为实验组,16 名 ASD 患者作为对照组,用频率为 1 Hz 的 rTMS 调控实验组,基于快速傅里叶变换提取额叶、顶叶、左颞叶、右颞叶、枕叶五个脑区的节律,用非参数估计中的 Welch 法计算四个频段的相对功率及额叶内通道之间的相干性,并分析所有 ASD 被试干预前后静息态脑电特征值的变化。统计实验组干预前后的孤独症行为量表(ABC),计算并比较干预前后各项指标得分。结果显示经过 rTMS 干预之后,ASD 患者右颞叶和顶叶 δ 频段的相对功率普遍降低,额叶通道之间的相干性降低。此研究表明 rTMS 能够改善 ASD 患者的注意力、执行能力、语言能力,减少刻板行为和过激行为

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