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-  2017 

发卡型寡聚酰胺对双链 DNA 的识别研究

DOI: doi:10.7507/1001-5515.201603004

Keywords: 发卡型寡聚酰胺, 双链DNA识别, 基因诊断, 基因治疗, 基因编辑

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Abstract:

对特定序列的双链 DNA(dsDNA)的识别是近几十年来生物医学和分子生物学等领域一大研究热点。利用原有的核苷酸或人工设计的化学分子配体与 dsDNA 序列之间的特异性识别作用,基因疾病诊断、基因治疗、基因编辑可以被实现。发卡型寡聚酰胺是一种能在 dsDNA 螺旋小沟处以较好的亲和力特异性结合 dsDNA 序列的分子配体,具有良好细胞膜通透性、胞内稳定性等优点。本文综述了发卡型寡聚酰胺对 dsDNA 的识别性质及其在生物化学、生物医学等方面的应用,为发卡型寡聚酰胺的设计及应用提供参考

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